Rectum & Colon Flashcards
(127 cards)
📖Types of colorectal polyps?
- pedunculated polyp:polyp has a stem
- sessile polyp: flat polyps
✂️Histologically, most polyps are🧷🧷🧷🧷🧷🧷
benign tubular adenomas
📝Full resection of these polyps does not require further intervention.
✂️The polyp is considered invasive carcinoma when tumor cells invade🧷🧷🧷🧷🧷
muscularis mucosa
What is the best next step after identifying a 1 cm pedunculated sigmoid polyp with adenocarcinoma invading only the submucosa and no distant spread⁉️
✅ Sigmoidectomy
➡️ Because cancer invaded the submucosa, surgical resection is needed to ensure complete excision and check for lymphovascular invasion or residual tumor.
What key colonoscopic and pathology findings indicate the need for surgical resection after polypectomy⁉️
🚩 Invasion of submucosa
🚩 Adenocarcinoma on biopsy
🚩 Polyp size ≥1 cm
➡️ These findings raise concern for residual tumor or lymph node spread.
What histological polyp types have a higher risk of malignancy⁉️
⛔ Villous and tubulovillous adenomas
⚠️ Risk increases with polyp size
➡️ Villous >2 cm = >50% malignancy risk
💡 Tubular adenomas <1 cm = ~5% risk
Does a completely resected benign tubular adenoma require additional treatment⁉️
✅ No
➡️ Full removal of a non-malignant polyp (especially if <1 cm) requires surveillance only, not further intervention.
What does T1 stage indicate in colon cancer TNM staging⁉️
✅ Tumor invades submucosa only ➡️ Early-stage lesion with favorable prognosis.
How is N staging defined in colon cancer⁉️
🚩 N0 – No regional lymph node metastasis
🚩 N1 – 1–3 positive lymph nodes
🚩 N2 – ≥4 positive lymph nodes
What is considered M1 in colon cancer staging⁉️
🚨 Presence of distant metastasis
What is the standard follow-up protocol after colon cancer surgery⁉️
📅CEA every 6 months for 5 years ➡️ then yearly
📅 Colonoscopy 1 year after surgery ➡️ then every 3 years if clean
🖥️ Chest + abdominal CT every year
🧠 CEA = Carcinoembryonic Antigen
What is the treatment and prognosis for Stage 1 colon cancer (T1/2 N0 M0)⁉️
✅ Surgery alone
🧠 5-year survival ≈ 90%
What is the treatment and prognosis for Stage 2 colon cancer (T3/4 N0 M0)⁉️
✅ Surgery (in general)
🧠 5-year survival ≈ 75%
What is the treatment and prognosis for Stage 3 colon cancer (N1/2 M0)⁉️
✅ Surgery ➕ Adjuvant chemotherapy:
➡️ FOLFOX (5-FU + Leucovorin + Oxaliplatin)
➡️ OR CAPOX (Capecitabine + Oxaliplatin)
🧠 5-year survival ≈ 50%
What is the treatment strategy for Stage 4 colon cancer (M1)⁉️
🚩 If unresectable: Chemotherapy ± targeted therapy (e.g., cetuximab)
🚩 If few resectable liver metastases: ➡️ Resection + chemo
5-year survival:
⛔ 5% (nonresectable)
✅ 60% (if resectable liver mets)
What are the major poor prognostic factors in colon cancer⁉️
⚠️ Lymph node involvement
⚠️ Liver metastases < 1 year after diagnosis
⚠️ CEA > 200 ng/mL
⚠️ >5 cm hepatic mets
⚠️ High-grade or mucinous/signet ring adenocarcinoma
⚠️ Bilobar liver involvement
⚠️ Lymphovascular/perineural invasion
⚠️ Extrahepatic metastases
What are the CEA monitoring guidelines after colon cancer surgery⁉️
✅ CEA (Carcinoembryonic Antigen) every 6 months for 5 years
➡️ Then annually
⚠️ If CEA is rising ➡️ do PET scan to assess for recurrence/metastases
(Carcinoembryonic Antigen)
When should colonoscopy be done after colon cancer surgery⁉️
✅ 1 year after surgery
➡️ If clear ➡️ repeat every 3 years
⚠️ If adenomas found ➡️ repeat annually until colon is clean
What imaging is recommended postoperatively in colon cancer patients⁉️
✅ Chest and abdominal CT every year
🧠 To monitor for local or distant recurrence
How are colorectal polyps classified based on endoscopic appearance⁉️
➡️ Pedunculated = with a stalk
➡️ Sessile = flat
What are the major types of colorectal polyps based on histology⁉️
🔹 Non-neoplastic:
▪️ Hyperplastic
▪️ Inflammatory
▪️ Hamartomas (e.g., Peutz-Jeghers)
🔹 Neoplastic:
▪️ Serrated
▪️ Adenomas (tubular, villous, tubulovillous)
▪️ Carcinomas
What features increase malignancy risk in neoplastic colorectal polyps⁉️
🚩 Size (larger = more risk)
🚩 Shape (sessile > pedunculated)
🚩 Histologic type (villous > tubular)
🚩 Grade of dysplasia
What are the indications for colectomy in colorectal polyps⁉️
🚨 Colectomy is indicated if:
✔️ Pedunculated polyp Haggitt level 4
✔️ Sessile polyp Kikuchi level SM2/SM3
✔️ Poor histologic differentiation
✔️ Lymphovascular invasion
✔️ Incomplete removal or positive margins
What clinical classification is used to assess severity of diverticulitis⁉️
✅ Hinchey classification is used to stage diverticulitis and guide treatment decisions.
(Other scoring systems like Ranson or APACHE are for pancreatitis, not diverticulitis.)