Reduced exocrine secretions ( pancreatinin insufficiency ) Flashcards Preview

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What causes reduced exocrine secretions ( pancreatin insufficiency) ?

cystic fibrosis, chronic pancreatitis, Zollinger-Ellison syndrome, coeliac disease, obstructive pancreatic tumours,


What dietary advice should be given ?

distribute food intake between three main meals and 2-3 snacks
avoid foods that are difficult to digest; legumes, high fibre foods
do not consume alcohol
avoid reduced fat diets


How does pancreatin supplements work ?

they assist with the digestion of starch, fat and protein


How to take pancreatin ( CREON) capsules ?

-take with meals/snacks or immediately before or after food : pancreatin is inactivated by gastric acid
- DO NOT mix with excessively hot food or drinks: pancreatin is inactivated by heat.
-if mixed with food or liquids: do not keep for more than 1 hour
-ensure adequate hydration at all times


What are the side effects of pancreatin ( CREON) ?

-GI side effects
-Irritation: perioral skin and buccal mucosa
-Excessive doses= perianal irritation, hyperuricaemia, hyperuricosuria, skin irritation and hypersensitivity when handling
-fibrosing colonopathy in cystic fibrosis with high dose pancreatin ( risk factors are male children, more severe cystic fibrosis and laxative use)