Regulation of Acid Base Balance

Question 1

[H+] in body

Answer 1

determined by ratio of [HCO3-]/Pco2
Pco2 regulated by lung
[HCO3] regulated by kidney
Lung compensates for metabolic [HCO3] disturbances
Kidney compensates for lung Pco2 disturbances (slow)

Question 2

Normal pH and [H+]

Answer 2

pH: 7.35-7.45

[H+] : 45-37 nEq/L

Question 3

Effects of Metabolic Acidosis

Answer 3

• Vasodilation (warn skin)
• Low CO
• Increased ventilation
• low GFR and urine pH
• fatigue and coma

Question 4

Effects of Metabolic Alkalosis

Answer 4

Arrhythmias
Seizures
Cramps/tetany
Seizures and polyuria

Question 5

[H+] and [OH-] synthesis

Answer 5

[H+] produced by urea synthesis

[OH-] produced by protein degradation and organic anions