Regulation of Food Intake Flashcards Preview

S&F IV: Exam One > Regulation of Food Intake > Flashcards

Flashcards in Regulation of Food Intake Deck (12):
1

Satiety Center

Ventromedial nucleus

2

Arcuate Nucleus

Main site of release of food-consumption regulating hormones

*Lacks complete BBB

3

Proopiomelanocortin Neurons

Produce a-MSH and CART which act to decrease food intake and increase energy expenditure by binding to MCR-3 & 4

-MCR projects to NTS to stimulate sympathetic nervous system

*CART negative/MCR-4 mutations => obesity

4

Orexigenic Neurons

Release AgRP and to increase food intake and decrease energy expenditure by inhibiting MCR-3 & 4 and stimulating Y-receptors (appetite) respectively

*Release is inhibited by insulin

5

Nicotine

Nicotine enhances the firing of POMC neurons

=>Increased a-MSH leads to decreased food intake and increased energy expenditure

6

Leptin

Hormone released by adipocytes when amount of fat increases

-Represses NPY/AgRP; stimulates POMC neurons

*Insulin leads to increased release/increased release will decrease insulin levels

7

Ghrelin

Released by the stomach and proximal SI; stimulates AgRP/NPY neurons

-Levels increase w/ stress, loss of sleep, diets, cancer anorexia

*Plasma levels normally rise before meals and fall after

ONLY OREXIGENIC HORMONE

8

GLP-1

Glucagon-like peptide 1

Released throughout the day by L-cells in the ileum and colon

-Stimulates satiety

9

OXM

Secreted by distal intestine in direct proportion to calorie ingestion

Quickly lessens hunger and food intake at a single meal

*Repeated injections would decrease body weight

*Acts much like PYY

10

Endocannabinoids

Stimulates orexigenic system and increases intake of fatty, sweet foods

*Decreased by leptin

11

Anorexia Nervosa Gastric hormones

Elevated NPY; Decreased leptin

12

Feeding Center

Lateral nucleus