Renal disease Flashcards

1
Q

What are the 10 structures of the kidney

A

1- renal cortex
2- renal medulla
3- renal capsule
4- minor calyx
5- major calyx
6- renal column
7- renal pyramid
8- renal papilla
9- renal pelvis
10- ureter

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2
Q

What is the nephron

A

A functional unit of the kidney.

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3
Q

What are the two main parts of the nephron

A
  • glomerules
  • tubule
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4
Q

What are the kidneys renal functions (6)

A
  • regulate volume of fluid in blood
  • electrolyte balance
  • acid-base balance
  • excretion of waste products
  • vitamin d metabolism
  • production of erythropoietin
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5
Q

What electrolytes does the kidney balance (6)

A
  • sodium
  • potassium
  • chloride
  • calcium
  • magnesium
  • phosphate
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6
Q

What waste products do kidneys excrete (3)

A
  • creative
  • urea
  • uric acid
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7
Q

What is erythropoietin

A

A growth factor for red blood cell production in bone marrow

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8
Q

What does the glomerulus do

A

Filtration

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9
Q

Where does the glomerulus filter fluid

A

The bowman’s capsule

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10
Q

What do the tubules do

A

Reabsorb and secrete

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11
Q

What are the 2 renal function tests

A
  • glomerular filtration rate
  • Measurement of waste products in plasma
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12
Q

How is the glomerular filtration rate test work

A

The volume of fluid filtered through all glomeruli per time unit.

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13
Q

What is the normal level for glomeruli per min

A

60-120 ml/min

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14
Q

How can this glomerular test be estimated

A

186 x (plasma creatinine 0.0113)^-1.15 x age^ -0.203 ( x 0.72 if female)

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15
Q

What is a normal estimated glomerular

A

Greater than 90 ml/min/1.73 m^2

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16
Q

What does a decreasing eGFR indicate

A

Impairment of renal function

17
Q

How does the measurement of waste products in plasma test work

A

Creatinine
- waste product of muscle breakdown
- easy to measure
- not sensitive marker of renal function

18
Q

How can acid base balence tests indicate renal failure

A

In renal failure there is metabolic acidosis (decreased acid excretion) so ph decreases and bicarbonate

19
Q

How can plasma phosphate indicate renal failure

A

The Kidney is involved in phosphate excretion so a decrease will show failure

20
Q

What causes acute renal failure (5)

A
  • hypovolaemia secondary to blood loss
  • acute inflammatory process affecting glomeruli
  • drugs affecting glomeruli
  • massive muscle breakdown
  • obstruction of renal blood or urine flow
21
Q

What is anuria

A

No urine output

22
Q

What biochemical changes happen in acute renal failure

A
  • decrease GFR
  • decrease urine volume
  • more plasma urea and plasm creatinine
  • more plasma k+
  • more plasma phosphate
23
Q

What causes chronic renal failure

A
  • diabetes
  • hypertension
  • diseases affecting glomeruli, tubules or renal interstitium