Renal Drugs Reverse

Question 1

Binds AngII receptors
Does not increase bradykinin

Answer 1

ARBs (-sartans) - mech (2)

Question 2

Carbonic anhydrase inhibitor
Gets rid of NaHCO3 from the body

Answer 2

Acetazolamide - mech

Question 3

CATCHH
Cough
Angioedema
Teratogen
Creatinine Up (b/c GFR down)
Hyperkalemia
hTN

Answer 3

ACEi (-prils) - side fx

Question 4

Direct renin inhibitor, blocks conversion of angiotensinogen to AngI

Answer 4

Aliskiren - mech

Question 5

Diuresis in patients allergic to sulfa drugs

Answer 5

Ethacrynic acid - use

Question 6

Drug overdose
Elevated ICP/IOP

Answer 6

Mannitol - use (2)

Question 7

Edematous states (HF, cirrhosis, nephrotic syndrome, pulmonary edema)
HTN
Hypercalcemia

Answer 7

Furosemide, bumetanide, Torsemide - use (3)

Question 8

Glaucoma
Urinary alkalinization
Metabolic alkalosis
Altitude sickness
Pseudomotor cerebri

Answer 8

Acetazolamide - use (5)

Question 9

HTN

Answer 9

Aliskiren - use

Question 10

HTN
HF
Idiopathic hypercalciuria
Nephrogenic diabetes insipidus
Osteoporosis

Answer 10

Chlorthalidone, Hydrochlorothiazide - use (5)

Question 11

HTN
HF
Proteinuria
Diabetic nephropathy (slows GBM thickening)
Prevents unfavourable heart remodeling in chronic HTN

Answer 11

ACEi (prils) - use (5)

Question 12

HTN
HF
Proteinuria
Diabetic nephropathy(If intolerance to ACEi)

Answer 12

ARBs (-sartans) - use (4)

Question 13

Hypderaldosteronism
K+ depletion
HF

Answer 13

Spironolactone/Eplerenone - use (3)

Question 14

Hypderaldosteronism
K+ depletion
HF

Answer 14

Triamterene, Amiloride - use (3)

Question 15

Hyperchloremic metabolic acidosis
Paresthesias
NH3 toxicity
Sulfa allergy

Answer 15

Acetazolamide - side fx (4)

Question 16

Hyperkalemia (arrhythmias)

Answer 16

Triamterene, Amiloride - side fx

Question 17

Hyperkalemia (arrhythmias)
Endocrine effects with spironolactone

Answer 17

Spironolactone/Eplerenone - side fx (2)

Question 18

Hyperkalemia
Decreased renal function
hTN
Cx in diabetics on ACEi/ARBs

Answer 18

Aliskiren - side fx

Question 19

Hyperkalemia
Decreased renal function
hTN
Teratogen

Answer 19

ARBs (-sartans) - side fx (4)

Question 20

Hypokalemic metabolic alkalosis
Hyponatremia
Hyperglycemia
Hyperlipidemia
Hyperuricemia
Hypercalcemia
Sulfa allergy

Answer 20

Chlorthalidone, Hydrochlorothiazide - side fx (7)

Question 21

Inhibit ACE to decrease AngII
Decrease GFR by preventing constriction of efferent arterioles
Bradykinin goes up because ACE can’t break it down

Answer 21

ACEi (prils) - mech (3)

Question 22

K+ sparing diuretic
Blocks Na channels in CCT

Answer 22

Triamterene, Amiloride - mech

Question 23

K+ sparing diuretic
Competitive aldosterone receptor antagonists in CCT

Answer 23

Spironolactone/Eplerenone - mech (2)

Question 24

OH DANG!
Ototoxicity
Hypokalemia
Dehydration
Allergy (sulfa)
Nephritis (interstitial)
Gout

Answer 24

Furosemide, bumetanide, Torsemide - side fx (6)

Question 25

OH DNG + can cause hyperuricemia

Answer 25

Ethacrynic acid - side fx

Question 26

Osmotic diuretic. Increases tubular fluid osmolarity to increase urine flow, decrease ICP/IOP

Answer 26

Mannitol - mech

Question 27

Phenoxyacetic acid derivative Same action as furosemide

Answer 27

Ethacrynic acid - mech

Question 28

Pulmonary edema Dehydration Contraindicated in anuria, HF

Answer 28

Mannitol - side fx (3)

Question 29

Sulfonamide loop diuretics Inhibits NaK2Cl channel of ascending Loop of Henle and prevents concentration of urine Stimulates PGE release (blocked by NSAIDs) Increases Ca excretion

Answer 29

Furosemide, Bumetanide, Torsemide - mech (4)

Question 30

Thiazide diuretic Inhibit NaCl reabsorption in early DCT to decrease diluting capacity of nephron Decreases Ca excretion

Answer 30

Chlorthalidone, Hydrochlorothiazide - mech (3)