Renal Embryology

Question 1

Pronephros forms in?

Answer 1

Week 4

Question 2

Functions as interim kidney for 1st trimester; later contributes to male genital
system?

Answer 2

Mesonephros

Question 3

Ureteric bud forms?

Answer 3

Collecting ducts=>Ureter

Question 4

Metanephric mesenchyme forms?

Answer 4

Glomerulus=>DCT

Question 5

Most common site of obstruction (hydronephrosis) in fetus? Why?

Answer 5

Ureteropelvic junction b/c last to canalize

Question 6

Explain Potter’s Sequence?

Answer 6

Oligohydramnios=>􏰂compression of developing fetus=>􏰂limb deformities, facial anomalies and lung problems

Pulmonary hypoplasia 
Oligohydramnios (trigger) 
Twisted face
Twisted skin 
Extremity defects 
Renal failure (in utero)

Question 7

What is the cause of death in patients with Potter?

Answer 7

pulmonary hypoplasia

Question 8

Causes of Potter?

Answer 8

ARPKD (Renal Genetic)
obstructive uropathy (e.g., posterior urethral valves), (Renal Obstruction)
bilateral renal agenesis. (Renal Insuff.)

Question 9

Inferior poles of both kidneys fuse?

Answer 9

Horseshoe Kidney

Question 10

Horseshoe kidney gets trapped under?

Answer 10

IMA

Question 11

What are some associations with Horseshoe kidney?

Answer 11

chromosomal aneuploidy syndromes (e.g., Edwards, Down, Patau, Turner)

Uteropelvic junction

Question 12

abnormal interaction between ureteric bud and metanephric mesenchyme? Sympathomatic or Asymptomatic

Answer 12

Multicystic dysplastic kidney

Asymptomatic

Question 13

Bifurcation of ureteric bud before it enters metanephric blastema creates Y-shaped bifid ureter? Associated with?

Answer 13

DuplexY collecting system

Vesicoureteral reflux and/or ureteral obstruction

Question 14

Bilateral Renal Agensis sequence of events?

Answer 14

BRA=>Oligohydramnios=>Potter’s sequence