RTA/Renal Tubular Defects Flashcards

1
Q

RTA 1? MOA?

A

Defect in ability of α intercalated cells to secrete H+=>metabolic acidosis

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2
Q

RTA 1 can lead to?

A

Increased risk of risk for calcium phosphate kidney stones

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3
Q

RTA 1 urine?

A

Distal (type 1), urine pH > 5.5

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4
Q

RTA 2? MOA?

A

Defect in PCT HCO3− reabsorption=> increased 􏰀excretion of HCO3− in urine

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5
Q

RTA 2 can lead to?

A

Increased risk for hypophosphatemic rickets.

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6
Q

RTA 4? MOA?

A

K-ALD=>hypoaldosteronism=>hyperkalemia=>􏰂􏰁NH4+ excretion

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7
Q

Generalized reabsorptive defect in PCT?

A

Fanconi syndrome=>RTA 2

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8
Q

Reabsorptive defect in thick ascending loop of Henle. Autosomal recessive?

A

Bartter syndrome

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9
Q

Reabsorptive defect of NaCl in DCT?

A

Gitelman syndrome

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10
Q

Gain of function mutation􏰂􏰀Na+ reabsorption in collecting tubules (􏰀activity of epithelial Na+ channel)?

A

Liddle syndrome

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