Renal Function Test Flashcards
The standard tests used to measure the filtering capacity of the glomeruli
Clearance test
Stability of substance in urine during 24- hour urine collection
Clearance test
Clearance test Reported in
mL/min
STANDARD METHOD for GFR
Urea clearance test
Demonstrate progression of renal
disease or response to therapy
Urea clearance test
REFERENCE METHOD for GFR
Inulin clearance test
Not routinely done because of the necessity for
continuous IV infusion
Inulin clearance test
Inulin clearance test PRIMING DOSE:
25ml of 10% inulin solution
Inulin clearance test CONTINUOUS INFUSION:
500ml of 1.5% inulin solution
Inulin clearance test
REFERENCE VALUES: male
127 ml/min
Inulin clearance test
REFERENCE VALUES: female
118 ml/min
Most commonly used; screening method of GFR
Creatinine clearance
waste product of muscle metabolism
Creatinine clearance test
Creatinine clearance
REFERENCE VALUES: Male
◦ 75- 112 mL/ min Female
85-125 mL/ min
Creatinine clearance
REFERENCE VALUES: Female
75- 112 mL/ min
Standard body surface
1.73 m2
Creatinine clearance MINUTES
1440 mins
Indirect estimate of GFR
Cystatin C
Completely reabsorbed by the PCT, hence its
presence in urine denotes damage to the
tubules
Cystatin C
good procedure for screening and monitoring
GFR.
Cystatin C
Cystatin C specimen
Serum or plasma (not fasting)
Cystatin C increase level
Acute and chronic renal failure
Cystatin C method
Immunoassay
Dissociates from human leukocyte antigens
at constant rate and is rapidly removed
from the plasma by glomerular filtration.
Beta 2 microglobulin