Renal pathology

Question 1

Drug induced interstitial nephritis

tubulointerstitial nephritis

Answer 1

Acute interstitial renal inflammation;

Pyuria (classically eosinophils) and azotemia occuring after drug admin that act as haptens, inducing hypersensitivity.

Question 2

Drug induced interstitial nephritis:

when does nephritis occur

Answer 2

Nephritis typically occurs 1-2 weeks after certain drugs

(diureti, penicillin derivatives, sulfonamide, rifampin) but can occur months after starting NSAIDs

Question 3

Drug induced interstitial nephritis:

presentation

Answer 3

Fever, rash, hematuria, and costovertebral angle tenderness, but can be asymptomatic

Question 4

Diffuse cortical necrosis

Answer 4

Acute generalized cortical infarction of both kidneys

Question 5

Diffuse cortical necrosis:

cause

Answer 5

Due to a combination of vasospam and DIC

Question 6

Diffuse cortical necrosis:

associated with

Answer 6

Associated with obstetric catastrophe
(e.g. abruptio placentae) and
septic shock