Renal Pharmacology Flashcards
(16 cards)
High ceiling diuretics
Loop diuretics
Moa - Na K 2 Cl inhibitors
Act on medulla portion of thick ascending limb
DOC for mountain sickness
Acetazolamide - increase H+ ions in blood and stimulate respi centre
Uses of carbonic anhydrase inhibitors
Glaucoma - inhibit secretion of aq humor
Cause alkalization of urine so weak acid drug Poisining Mei used
Mountain sickness
Contra indication of CA -
Liver dis as they cause increase in NH3
Why aspirin should not be given with diuretics
Aspirin : decrease PG synthesis
GFR reduced has antidiuretic effect
Which diuretic CI in heart failure
Mannitol as it increase preload
DOC IN NEPHROGENIC DI
Thiazide diuretics
Also doc in hypertension
Impotence caused by which diuretic
Spironolactone and thiazide
Types of K sparing diuretics
Aldosterone receptor antagonist : spironolactone
Epleronone
ENaC inhibitors : Amiloride
Triamterene
Doc in Liddle syndrome
Amiloride
Loop and thiazide cause which acid base disorders
Hypokalemic met alkalosis
Carbonic anhydrase which met disorder
Hypokalemic met acidosis
ADH act in which receptors
ADH - supraventricular nucleus
3 receptors
* V1 - vasocontstriction
* V2 - endothelium VWf and factor 8, kidney : CD aquaporine 2
* V3 - Gq pituitary
V2 agonist eg and use
Desmopressin
Route : Oral and intranasal
Given in hemophilia A
Vwf deficiency
Neurogenic and central DI
Nocturnal enuresis
Drugs causing DI
Lithium
Alcohol
Phenytoin
Amophotericin B
Rifampicin
Methoxyflurane
Drugs causing SIADH
Carbamazepine
Chlorpropamide
Cephalosporins
Anti depressant like ssri
Cancer drugs like vincristine taxane actinomycin D
