Flashcards in Renal Therapeutics 1: PM1A kidney notes Deck (15):
What is the function of the renal system?
1. Homestatic regulation of water and inorganic ion balance
2. Removal of metabolic waste products and foreign chemicals from the blood and their excretion in urine
What are the three processes of the elaboration of the urine?
1. Filteration occurs in the glomerulus
- Filtration of blood plasma forms filtrate this enters the tubules (now called tubular fluid)
- Movement from tubular fluid to blood (transcellular or paracellular)
- Movement from blood to tubular fluid
What molecules form the filtrate and what cannot form it?
Water, Urea and glucose can
Inulin, myoglobin, haemoglobin, Albumin (proteins) cannot
What is diabetes insipdus caused by?
1. The inability of the kidneys to conserve water (frequent urination and extreme thirst)
2. This is due to a lack of ADH due to damage to hypothalamus or result of surgery or pituitary gland
If you have micturition abnormalities, what does normally arise from?
Lower urinary tract problems such as infection, inflammation
What do fluid and electrolyte imbalances commonly result from?
Renal impairment caused from haemodynamic consequences with cardiovascular features (BP, oedema, shortness of breath)
What do osmotic imbalances commonly result from?
What do uraemia commonly result from?
1. Symptoms of renal failure (high level of blood urea)
2. Azotaemia (high level of nitrogenous products)- lethargy, nausea, vomiting, anorexia
What does the rate of filtration measure?
Efficacy of the kidney but difficult to measure
What does clearance measure?
Hypothetical volume of blood from which a substance would be completely removed by filtration in 1 minute
What does it mean when plasma clearance is less than GFR?
When substance is filtered and reabsorbed but it isn't secreted (urea and glucose)
What does it mean when plasma clearance is more than GFR?
The substance is filtered and secreted, but not reabsorbed (PAH and paraaminohippuric acid)
What substance is freely filtered from the blood capillaries into the bowmans capsule, neither reabsorbed or secreted by the tubules and has no overt effect on renal metabolism?
Plant polysaccharide inulin and creatinine (produced at a fairly constant rate in the muscle)
What is used to measure the GFR normally and why?
Creatinine- just filtered, no reabsorption, little bit of secretion