Renal (Thiazide Diuretics)

Question 1

Examples of drug (Thiazide Diuretics)

Answer 1

• Bendroflumethazide
• Indapamide
• Chlortalidone

Question 2

Mechanism of action (Thiazide Diuretics)

Answer 2

• Inhibit Na+/Cl- transporter at the distal convoluted tubule and collecting duct
• Increases Na+, Cl- and water excretion

Question 3

Indications (Thiazide Diuretics)

Answer 3

• Hypertension

- Oedema of cardiac / renal / hepatic / iatrogenic origin

Question 4

Side effects (Thiazide Diuretics)

Answer 4

• Hypokalaemia
• Hypomagnesaemia
• Hyponatraemia
• Hypercalcaemia
• Hyperuricaemia
• Reduced glucose tolerance
• Hypersensitivity reactions – rashes, pneumonitis (less common)

Question 5

Important pharmacokinetics/pharmacodynamics (Thiazide Diuretics)

Answer 5

• Produces diuresis quickly within 1-2 hours
• NSAIDs reduces efficacy of thiazide diuretics
• Note that urinary symptoms are less common with the lower doses used for the treatment of hypertension.

Question 6

Patient information (Thiazide Diuretics)

Answer 6

• Urinary frequency usually not affected
• Report if sudden rash
• Make aware of risk of electrolyte imbalance