Renal Urinary System Flashcards
(45 cards)
What does Renin do?
Regulates Kidney function, increase blood NaCl, volume and pressure
Erythropoietin
Cytokine for CFU-E, increase RBC’s
Cortex of Kidney contains:
Corpuscles and tubes
Medulla of kidney contains:
only tubes
How kidney maintains homeostasis
- regulates and exchange to adjust blood chemistry
- mediated by membrane transporters
What percent does the PCT recover?
65%
Where is the highest salt concentration ?
loop of Henle
Where in the nephron does it selectively recover NaCl and secrete H+ and HCO3-?
Collecting Tubules and ducts
Where does the nephron selectively recover water
Late distal tubule, collecting tubules and ducts
What regulates filtrate formation
JGA
Name the area that leads to the PCT?
Urinary Pole
Glomerular Mesangial Cells
physically support capillaries,
Turn over basal lamina,
contractile control capillary diameter (filtration rate),
signaling
What makes up the glomerular filtration barrier
-Fenestration capillary endothelium
-glomerular basement membrane(blocks large proteins)
Filtration slitsbetween pedicelts
What makes up the Filtrate
Water, glucose, amino acids, ions urea, hormones, vitamins B and C, ketones and small amounts of protein
Proteinuria
indicator of many kidney disorders
What drives filtration?
blood pressure
How much fluid moves from the blood to initial filtrate?
about 20%
How much fluid does the PCT return?
65%, 120-130 l/day
what is the PCT made of?
Simple columnar
How does the PCT move particles?
by gradient
What does the reabsorbed particles in the PCT enter
peritubular capillaries ( particles are isosmotic)
How are proteins leaking into filtrate taken back up?
pinocytosis at base of microvilli
hydroxylase reaction creates:
Vitamin d2 and D3
PCT reabsorps:
AA’s, GLu, Po4, small protein-hormones and water into peritubule capillaries
