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Flashcards in reoviridae Deck (25):
1

reoviridae

REO-> respiratory enteric orphan

2

reoviridae general

nonenveloped, spherical, ds RNA segments 10-12 depending on genus, replication in cytoplasm
segments allow for genetic reassortment

3

subfamilies of reoviridae

sedoreovirinae and spinareovirinae

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sedoreovirinae important genera

orbivirus-african horse sickness, blue tongue virus
rotavirus-RVA

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spinareovirinae important genera

orthoreovirus-avian reovirus
coltivirus-colorodo tick fever virus

6

blue tongue

most susceptible host-sheep, fine wool in europe and white-tailed deer. Inapparent infection in cattle which are primary reservoir and amplifying host

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Blue tongue (BTV)

List A disease, part of orbivirus
10 segments dsRNA genome

8

BTV transmission

transmitted biologically by certain species of culicoides sonorensis
can be venereal or trans placental transmission

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BTV path

vascular endothelium damage, intravascular coagulation, necrosis of tissues and organs, edema, hemorrhage, congestion, abortion, CNS malformations

10

BTV clinical findings

profuse salivation, edema of muzzle, reddening of nasal mucosae, mucopurulent nasal discharge, often blood stained, crust formation on nostrils and lips
cyanosis on the tongue, necrotic ulceration, erosion of dental pad, necrosis, hyperemia, ulceration in oral cavity, coronitis and laminitis

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Dx of BTV

immunohistochemical tests such as immunoflourescence and immunoperoxidase test, PCR, ELISA

12

african horse sickness (AHS)

infectious, noncontagious, arthropod bourne disease of horses, donkeys and mules, sometimes dogs List A disease enzootic to sub saharan africa

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AHS etiology

orbivirus, nine serotypes based on capsid protein VP2 and VP5 variation

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AHS transmission

cullicoides regularly in most countries of subsaharan africa

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AHS clinical findings

profuse nasal discharge od serous and froth that may be blood stained, pulmonary edema, interlobular edema of lungs, hydroperitoneum, hydropericardium, edema of muscles, edema of eyelids

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AHS prevention and control

vaccination in enzootic areas, control of vector, reduced exposure to biting insects, slaughter of sick or viremic

17

rotavirus

major cause of sever viral diarrhea in young animals and birds, 11 segments of dsRNA, VP6 protein variations, RVAs cause the diarrhea

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RVA strain Wa: G1P1A(8)

G1= is G genotype/serotype
P1A(8): 1 A is P serotype
(8) is Pgenotype

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rotavirus transmission in animals and humans

infected stool has large number of visions, fecal oral transmission, virus replicates in mature enterocytes on the villi of upper small intestine

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rotavirus pathogenesis

after ingestion can either infect intestinal villus cells damaged during virus replication and release or NSP4 acts as an enterotoxin

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rotavirus symptoms

severe diarrhea in young of different animals, profuse diarrhea, anorexia, dehydration and occasionally mild fever, feces are watery to pasty pale yellow sometimes filled with mucous and blood flecks

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rotavirus Dx

PAGE gel

23

avian reovirus

viral arthritis/tenosynovitis
broilers, turkeys, transmission fecal oral, arthritis common in the hock joint

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avian reovirus clinical findings

lameness, tensosynovitis, swollen and inflamed hock joints, clear synovial fluid and inflammation of synovial membranes, ruptured gastrocnemius tendons

25

avian arthritic prevention

live and killed vaccines available, passive immunity to chicks