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Flashcards in arteriviridae Deck (12):

arteriviridae general

enveloped, spherical, linear + sense ss RNA, infectious RNA, frequently establish persistent infections, cytoplasmic replication,
ER budding off virions released by exocytosis


equine arteritis

one serotype, equine host, present in most countries, occur through lateral spread, venereal transmission (natural or artificial breeding) , and horizontal transmission, respiratory route most common, stallion is reservoir,
mares always infected, transplacental transmission can occur


equine arteritis path

macs and endothelial cells are site of replication, causes damage to blood vessels leading to generalized edema and hemmorhages, replication in semineferous tubules can cause infertility, cross of virus to fetus cases fetal death because of necrotizing myometritis and placental detachment


equine arteritis clinical signs

adult horses- primary infection is asymptomatic, fever, depression, anorexia, limb edema, edema of prepuce, scrotum, mammary gland, urticaria
neonatal foals- interstitial pneumonia and enteritis


repro clinical signs in horses

mare-abortion or congenital defects
stallion-short term sub fertility, not due to direct effect of virus because of increased intratesticular temperature


Dx equine arteritis

necropsy for common lesions of edema, congestion, and hemorrhages of SQ tissue, lymph nodes and visceral organs


arteritis control

vaccinate colts and noncarrier stallions, carrier stallions manages separately and bred only with seropositive mares


porcine reproductive and respiratory syndrome (PRRS)

Swine mystery disease, blue ear disease, arterivirus, only infects wild and domestic pigs, aerosol, direct contact, infected semen, transplacental transmission
piglets may be born viremic and transmit infection up to 112 days after birth


PRRS path

replication in macs in lungs and lymphoid tissues, lesions include lymph node enlargement and interstitial pneumonia, 2 phases-repro failure and respiratory disease post weaning


repro failure PRRS

late term abortion, SMEDI, gross lesions in umbilical cords


respiratory syndrome PRRS

severe resp distress, necrotizing interstitial pneumonia, fever, red discoloration of body, pericarditis


PRRS control and diagnosis

control- live attenuated and inactivated vaccines, control of PRRS by exclusion