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repro drugs 1 Flashcards

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1
Q

letrozole

A

aromatase inhibitor - Hormone + breast cancer

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2
Q

anastrozole

A

aromatase inhibitor - Hormone + breast cancer

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3
Q

exemestane

A

aromatase inhibitor - Hormone + breast cancer

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4
Q

norethindrone

A

synthetic progestin –> use in depo contraception

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5
Q

estradiol cypionate

A

estrogen used for ERT b/c longer duration than unmodified E2

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6
Q

raloxifene

A

“SERM that blocks E2 signaling in breast & uterus- used for hormone sensitive cancer
agonist in bone and CV system”

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7
Q

mifepristone/RU486

A

“blocks progesterone activity by recruiting co-repressor

type II antagonist”

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8
Q

ethinyl estradiol

A

estrogen used for hypogonadism and contraception

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9
Q

mestranol

A

estrogen used for hypogonadism and contraception

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10
Q

finasteride

A

inhibits 5-alpha reductase - targets type II - so targets prostate enlargement & male-pattern baldness

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11
Q

flutamide

A

anti-androgen drug for prostate cancer - messes with ARA70

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12
Q

nilutamide

A

anti-androgen drug for prostate cancer

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13
Q

cyproterone acetate

A

anti-androgen drug for prostate cancer

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14
Q

clomiphene

A

used for infertility in PCOS

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15
Q

olaparib

A

PARP inhibitors - for tx of breast cancer with BRCA1/2

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16
Q

carboplatin + paclitaxel

A

chemo of choice for ovarian cancer

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17
Q

BEP - bleomycin, etoposide, cisplatin

A

chemo regiment for germ cell tumors (women)

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18
Q

alprostadil

A

“erectile dysfunction drug
PGE1 analogue
intracavernosal injection or intrameatal application”

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19
Q

PDE 5 inhibitors

A

“erectile dysfunction drugs
inhibit cGMP phosphodiesterase isozyme 5 –> maintains vasodilation
work quickly - peak plasma in 30 - 90 minutes
metabolized by CYP3A4 to an active metaboliste”

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20
Q

pentoxyphylline

A

“used to activate epidydimal and testicular sperm for ICSI

for pts with no sperm in ejaculate”

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21
Q

tx of PCOS

A

“oral contraceptive pills/cyclic progesterone
anti-androgens
weight loss
insulin sensitizing agents”

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22
Q

MMP-9

A

enzyme critical for implantation

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23
Q

diazoxide

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A

drug used for hyperinsulinimia –> works on K ATP channel

24
Q

somatostatin

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A

“drug for hyperinsulinimia –> blocks Ca+ influx the leads to insulin release
used for somatatrop adenoma (GH)”

25
dopamine agonist
"used for somatotroph adenomas paradozical effect - stimulates production in normal cells but inhibits GH release in adenoma cells cabergoline"
26
somatostatin analogs
"bind to somatostatin receptors on somatotroph cells & inhibits GH release treats thyrotroph adenomas - reduce secretion of TSH & size of adenoma octreotid & lanreotide"
27
GH receptor antagonist
"bind to growth hormone receptors and prevent GH from binding --> precents dimerization pegvisomant most effective current drug for normalization of IGF-1 levels"
28
dopamine agonist
"used for lactotroph adenoma & hypercortisolism cabergoline & bromocriptine"
29
leuprolide
"GnRh agonist at pituitary | used in prostate cancer"
30
pasireotide
somatostatin analog - inhibits ACTH secretion for hypercortisolemia
31
cabergoline
dopamine agonist used to inhibit ACTH secretion for hypercortisolism
32
eplerenone
txs primary hyperaldosteronism & K+ sparing volume depltion/ diuretic
33
amiloride
"tx for hyperaldosteronism | inhibits ENaC"
34
spirinolactone
"K+ sparing diuretic (CHF, essential HTN, cirrhosis, nephrosis ), primary hyperaldosteronism, PCOS/hirtuism more side effects b/c less specific - gynecomastia, descrease libido, impotence - also binds androgen & progestrone receptors"
35
metyrapone
"tx for hyperaldosteronism - inhibits steriodogenesis | inhibits 11 beta hydroxylase"
36
mitotane
tx for hypercortisolism - cytotoxic to adrenal cells
37
mifepristone
tx hypercortisolism by blocking glucocorticoid receptor
38
eplerenone
"decreases action of mineralocorticoids --> prevents binding of aldosterone to mineralocorticoid receptor --> reducred upregulation of Enac, K+ channel & sodium/potassium pump"
39
PTU
"antithyroid med- used after methimazole - more side effects dosed 3x daily starting does 100 mg USE methimazole in all Grave's pt except: first trimester pregnancy thyroid storm adverse rxn to methimazole"
40
methimazole
"antithryroid med - inhibits synthesis of t4/t3 fewer drug induces lupus, vasculitis, hepatitis starting does 10 - 30 mg"
41
progestin therapy
"replacement therapy contraception & IVF endometriosis dysfunctional uterine bleeding"
42
lupron
"acts as an agonist at pituitary GnRH receptors. | Used to delay precocious puberty"
43
goserelin
LH-RH agonist - used for prostate cancer
44
tx of BRCA-1 cancers
"increased sensitivity to cisplatin reduced sensitivity to taxanes ParP inhibitors"
45
octeotride
"somatotroph analogue used to reduce GH secretion in somatrotroph adenoma used to inhibit insulin release in insulinoma or hyperinsulin secretion acts on KatP channel and affects translocation of Ca --> directly inhibits insulin secretion (SE of this use are suppression of GH, TSH, ACT)"
46
somatostatin actions
"ibhibits GH release in pituitary inhibits TSH, PRL in pituitary glucagon & insulin in pancreas"
47
what drugs cause primary adrenal insufficiency
aminoglutethimide, ketoconazole, etomidate, rifampin, phenytoin
48
ketoconazole
"inhibits enzymes in steroidogenesis pathway used in hypercortisolism need to check liver fx"
49
amiodarone
"used to tx arrhymthemias - 37% iodine | can cause hyper or hypo thyroidism"
50
bisphosphonates
"osteoporosis drug that inhibits osteoclast activity & promotes osteoclast death first line"
51
denosumab
osteoporosis drug that inhibits osteoclast activity & inhibits RANKL
52
teriparatide
"anabolic agent - increase osteoblast activity can only use for two years --> will lead to bone absorption avoid in states of high turnover"
53
calcitonin
"osteoporosis drug that inhibits osteoclast activity | third line - only use for acture fracture and pain"
54
serm
osteoporosis drug that inhibits osteoclast activity - ER agonist on bone - anti-resorptive
55
estrogen
osteoporosis drug that inhibits osteoclast activity

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