Repro - Female

Question 1

hormones @ puberty

Answer 1

nighttime pulse GnRH

down sensitivity to negative feedback from gonadotrophs

Question 2

hormones @ repro years

Answer 2

pulse GnRH
LH > FSH
E, P, inhibin, activin

Question 3

hormones @ menopause

Answer 3

no more neg feedback from ovaries
LH, FSH go way up
FSH > LH (decrease in inhibin)

Question 4

menstrual phases

Answer 4

follicular
ovulatory
luteal

Question 5

follicular phase

Answer 5

day 0 - 14
goal: dev follicle, prep uterus for P
growth of dominant follicle --> E
E --> granulosa make more E
E --> up E and FSH receptors
E --> inhibit GnRH
FSH dip --> other follicles atresia
LH slowly increasing (need E and P to inhibit)

Question 6

ovulatory phase

Answer 6

~12 hrs post LH surge
goal: release oocyte
when follicle mature, E:P up –> LH surge
LH surge –> stop E synth by follicle (inhibit aromatase)
LH –> reinitiate meiosis
LH –> prostaglandins –> ovulation
LH –> follicle change to luteal

Question 7

luteal phase

Answer 7

14 days until menstruation 
goal: form CL, up P, prep uterus
follicle dies --> E drops (- feed again)
inhibin - neg feed
LH stim CL to make E and P*
P inhibits LH and FSH
when CL dies --> LH drops

Question 8

uterine phases (+ ovarian link)

Answer 8

menses (follicular)
proliferative (follicular)
secretory (luteal)

Question 9

hormones to start menstruation

Answer 9

drop in E and P from dead CL

release of prostaglandins (contract vessels, contract myometrium)

Question 10

proliferative phase

Answer 10

change endo from increased E

Question 11

secretory phase

Answer 11

due to increase in P
inhibit E
uterus secretes glycogen-rich secretion
endo CT becomes loose and edematous
inhibit contractions