Reproductive Pathology Flashcards
(29 cards)
Breast tissue anatomy
Parenchymal tissue - glandular
Connective tissue
Parenchymal tissue
Branching duct system Terminal duct lobular units Subsegmental duct Segmental duct Collecting/lactiferous duct Nipple
Secretory portion of breast tissue
Terminal duct lobular units
Cell layers of ductal lobular system
Inner epithelial cells
Outer myoepithelial cells
Myoepithelial cell markers
SMM
p63
ck5/6
Breast disease classification
Inflammatory
Proliferative
Neoplastic
Inflammatory breast disease
Actue / Chronic mastitis
Mammary duct ectasia - dilation
Fat necrosis
Proliferative breast disease
Fibrocystic change
Radial scar
Neoplastic breast disease
Benign:
Fibroadenoma
Papilloma
Malignant: Carcinoma Sarcoma Paget's disease Phylloides tumour
Diffuse breast lumps
Fibrosis
Discrete breast lumps
Neoplasm
Cyst
Abscess
Hamartoma
Mobile breast lumps
Benign neoplasm
Tethered breast lumps
Tethered carcinoma
Milk nipple discharge
Pregnancy
Blood nipple discharge
Duct papilloma
Carcinoma
Nipple retraction
Invasive carcinoma
Nipple erythema
Paget’s disease
Eczma
Fibrocytic changes in breast tissue
Cycle E2 secretion Breast epithelium proliferation Burst Inflammation Fibrocytic change
Fibrocytic change in breast tissue age group
25 - 45 yrs
Fibroadenoma
Benign - no Rx
20-35 yrs
Proliferating ducts and connective tissue
Fibroadenoma size changes
Increases size in pregnancy
Decreases size with age
Phylloides tumour
40-60 yrs
Epithelial and mesenchymal elements
Benign or Malignant
Phylloides tumour Mx
Wide local excision
RFs for breast carcinoma
F Age Early menarche Late menopause 1st pregnancy > 30 yrs Obesity FH
