Respiratory Flashcards
(125 cards)
Describe the pathophysiology of asthma
Reversible increased resistance to airflow due to airway narrowing during attack. Patients have normal physiology between the attacks. Caused by bronchospasm or inflammation.
Airway narrowing in asthma is caused by?
- bronchospasm
- inflammation
What are the triggering factors for Asthma
- Airway irritants
- Exercise, cold air, dry air
- Resp infection; upper/lower
- ASA from overproduction of leukotriens
- Beta blockers
- GERD
Identify the clinical features of asthma
- SOB Cough,
- chest tightness
- Wheezing
- Dyspnea
- Worst at night
What are the physical exam findings of Asthma between attacks
- Normal physical examination
- Abnormal PFT
What are the physical exam findings of Asthma during attacks
- Tachypnea
- Inspiratory and expiratory wheezing
- Use of accessory muscles
- pulsus paradoxus
- Paradoxical movement of abdomen
Identify the diagnosis criteria for asthma
Decreased Peak flow expiratory rate
FVC, FEV1 and FEV1/FVC decreases
- Increased RV
- Normal diffusion capacity
- Improvement of flow rate with bronchodilators
- Bronchial hyperesponsiveness to histamine
- Eosinophilia
- CXR: hypeinflation; flatening of diaphragm; mucus plug; atelectasis
- ABG: Hypocapnia; Mild hypoxemia; Hypocarbia is common
What are CXR diagnostic findings for asthma
- Hypeinflation
- Flatening of diaphragm
- Mucus plug .
- Atelectasis
What are the ABG diagnostic findings for asthma
Hypocapnia
Mild hypoxemia
Hypocarbia is common
Tachypnea in presence of normal or high CO2 (40@40) = Respiratory Emergency, respiratory failure will occur. Intubation is indicated.
Describe the treatment of asthma
Anti-inflamatory drugs
Bronchodilators
Anti-leukotrienes- Zileuton(Zyflo)
Montelukast (Singulair) and Zafirlukast
Anti-IgE monoclonal therapy
Describe the use of Anti-inflamatory drugs for treatment of Asthma
- Inhaled Steroids
- Systemic Steroids
- Cromolyn to prevent mast cell degranulation
This drug is used only for prophylaxis and not acute asthma attacks. It can also be used to prevent exercise induced asthma
Cromolyn
Describe the use of bronchodilators for treatment of Asthma
- Beta 2 agonists
- Anticholinergics
- Aminophyline preparations
- theophyline: PDE inhibitor with narrow therapeutic index
This drug is a PDE inhibitor with a narrow therapeutic index, used as a bronchodilator
theophyline
Describe the use of Anti-leukotrienes- Zileuton(Zyflo) for treatment of Asthma
- 5-lipoxigenase inhibitor
- Blocks conversion of arachidonic acid to leukotriene
- Adverse effects; Dyspnea, arthralgia, chest pain, fever
This drug can cause Dyspnea, arthralgia, chest pain, and fever
Anti-leukotrienes- Zileuton(Zyflo)
Describe the use of Montelukast (Singulair) and Zafirlukast for treatment of Asthma
- Competitive antagonist of leukotriene on cysteinyl-leukotriene1 receptor.
- Prevent bronchospasm, vasoconstriction and eosinophil recruitment.
- Good for aspirin induced asthma
Blocks the conversion of arachidonic acid to leukotriene
Zileuton (zyflo): 5-lipoxygenase inhibitor
Competitive antagonist of leukotriene on cysteinyl-leukotriene1 receptor
Montelukast (singulair) and Zafirlukast
Describe the use of Anti-IgE monoclonal therapy for treatment of Asthma
Use Omalizumab which binds free IgE
This drug binds free IgE
Omalizumab
Describe the management of acute asthma attack
- Beta agonist + steroid + ipatropium
- Systemic steroids IV
- Aminophyline not effective in severe acute attack
Describe the management of chronic asthma
Inhaled steroids as maintenance + beta 2 agonist for symptomatic control
Add ipatropium
Consider aminophyline
Short course steroids
3 messenger systems for bronchial smooth muscle tone are?
Beta 2 stimulant via Gs Protein
Nitric oxide via cGMP
Cholinergic muscarinic via IP3






