RESPIRATORY DISORDERS Flashcards Preview

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Flashcards in RESPIRATORY DISORDERS Deck (17):
1

what is cystic fibrosis?

Cystic fibrosis is an inherited condition in which the lungs and digestive system can become clogged with thick, sticky mucus.

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2

explain cystic fibrosis in a molecular level

misfolded> can't migrate from the ER to the Cell membrane> Lack of CFTR protein

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3

Explain in order the organs affected in cystic fibrosis?

NewBorn>> colon

Early childhood>> pancreas

Adults>> lungs

4

what is another name for cystic fibrosis?

"fibrocystic disease of the pancrea"

5

explain in detail what happens to the newborns in cystic fibrosis?

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6

explain in detail what happens to the pancreas in cystic fibrosis?

backed up pancreatic enzymes can digest the pancreatic duct.

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7

explain in detail what happens to the lungs in cystic fibrosis?

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8

what test do we perform to confirm the diagnosis of cystic fibrosis and why?

Sweat test> abnormally salty sweet

the anscence of the CFTR on the apical membrane of the epithelial cells lining the duct of sweat glands, results in poor re-absorption of the chloride ions. Cl-

therefore, the sweat is rich in Cl- & Na+ ions

9

what other issues in the body may be caused by cystic fibrosis? (3)

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10

why r men w/ cystic fibrosis infertile?

due to abscence of the VAS DEFERNS

 

Vas Deferens: the duct which conveys sperm from the testicle to the urethra.

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11

what lung problems can occur from cystic fibrosis?

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12

due to cystic fibrosis, what can the chronic bacterial infection and inflammation lead to?

occasionally, if the inflammation erodes into a BV > hemoptysis (coughing up blood)

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13

Diagnosis of CF?

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14

difference in CFTR roles in sweat glands vs lungs and pancreas?

unlike in lungs an pancreas where chloride can get out (into the mucous) , when CFTR is not working in the sweat glands, Cl- can't come in! or be re-absorbed >> making sweat tastes salt. 

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15

Treatment of CF?

chest physiotherapy: pats on chest to loosen up mucous

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16

Personalized treatments of CF?

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17

what kind of disorder is CF? (genetic level) epidemiology?

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