Respiratory-Pharmacology Flashcards
What are some 1st gen H1 receptor blockers?
Diphenhydramine,
dimenhydrinate,
chlorphenireamine
What are the clinical uses of 1st gen H1 receptor blockers?
allergies, motion sickness, sleep aid
What are the toxicities of 1st gen H1 receptor blockers?
sedation, antimuscarinic, and anti-a-adrenergic
What are some 2nd gen H1 receptor blockers?
Loratadine, fexofenadine
desloratadine
Cetirizine
What are the clinical uses of 2nd gen H1 receptor blockers?
allergies
What are some expectorants?
Guaifenesin
N-acetylcysteine
How does Guaifenesin work?
it thins respiratory secretions but does not suppress cough reflex
How does N-acetylcysteine work?
It is a mucolytic that can loosen mucuous plugs of CF pts. by disrupting disulfide bonds.
What is another use for N-acetylcysteine?
antidote for acetaminophen overdose
What is Dextromethorphan?
An antitussive that works by antagonizing NMDA glutamate receptors
NOTE: since this is a synthetic codeiene analong, it can produce a dissociation syndrome in high dose
How can Dextromethorphan overdose be treated?
Naloxone
Dextromethorphan has been linked to what potential complication?
Serotonin syndrome
What is serotonin syndrome?
Symptoms include high body temperature, agitation, increased reflexes, tremor, sweating, dilated pupils, and diarrhea. Body temperature can increase to greater than 41.1 °C (106.0 °F). Complications may include seizures and extensive muscle breakdown.
Typically this occurs only under the use of 2+ serotonergi agents
What are psuedoephredine and phenylephrine?
a-adrenergic agonists (can be used as nasal decongestants)
What are some categories of drugs used to tx PAH?
- Endothelin receptor anatongists
- PDE-5 inhibitors
- Prostacyclin analogs
Study these from class deck
