Respiratory-Pharmacology Flashcards Preview

STEP 1 (1) > Respiratory-Pharmacology > Flashcards

Flashcards in Respiratory-Pharmacology Deck (15):
1

What are some 1st gen H1 receptor blockers?

Diphenhydramine,

dimenhydrinate, 

chlorphenireamine

2

What are the clinical uses of 1st gen H1 receptor blockers?

allergies, motion sickness, sleep aid

3

What are the toxicities of 1st gen H1 receptor blockers?

sedation, antimuscarinic, and anti-a-adrenergic

4

What are some 2nd gen H1 receptor blockers?

Loratadine, fexofenadine

desloratadine

Cetirizine

5

What are the clinical uses of 2nd gen H1 receptor blockers?

allergies

6

What are some expectorants?

Guaifenesin 

N-acetylcysteine

7

How does Guaifenesin work?

it thins respiratory secretions but does not suppress cough reflex

8

How does N-acetylcysteine work?

It is a mucolytic that can loosen mucuous plugs of CF pts. by disrupting disulfide bonds. 

9

What is another use for N-acetylcysteine?

antidote for acetaminophen overdose

10

What is Dextromethorphan?

An antitussive that works by antagonizing NMDA glutamate receptors 

NOTE: since this is a synthetic codeiene analong, it can produce a dissociation syndrome in high dose

11

How can Dextromethorphan overdose be treated?

Naloxone

12

Dextromethorphan has been linked to what potential complication?

Serotonin syndrome

13

What is serotonin syndrome?

Symptoms include high body temperature, agitation, increased reflexes, tremor, sweating, dilated pupils, and diarrhea. Body temperature can increase to greater than 41.1 °C (106.0 °F). Complications may include seizures and extensive muscle breakdown.

Typically this occurs only under the use of 2+ serotonergi agents

14

What are psuedoephredine and phenylephrine?

a-adrenergic agonists (can be used as nasal decongestants)

15

What are some categories of drugs used to tx PAH?

-Endothelin receptor anatongists

-PDE-5 inhibitors

-Prostacyclin analogs

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