Retroviruses

Question 1

Unique life cycle of retroviruses

Answer 1

• reverse transcription
• integration into host chromosome

RNA –> DNA (reverse transcription) –> Provirus (integration)

Question 2

Classifications of retroviruses

Answer 2

• Oncoviruses
• Lentiviruses
• Spumaviruses
• Endogenous retroviruses

Question 3

Oncovirus example

Answer 3

Delta: Human T-cell lymphotrophic virus

Question 4

Lentivirus example

Answer 4

HIV

Question 5

Endogenous retrovirus example

Answer 5

HERV-K

Question 6

HERV

Answer 6

• comprises 8-10% of human genome
• derived from persistent infection
• Most HERVs are defective
• Some expected to be associated with human diseases

Question 7

Which HERV types are associated with human dzs?

Answer 7

• HERV-K

- HERV-W

Question 8

What are long terminal repeats LTRs?

Answer 8

cis elements required for:

• reverse transcription
• viral gene transcription
• splicing
• virus integration
• packaging