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Flashcards in Retroviruses Deck (8)
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1

Unique life cycle of retroviruses

- reverse transcription
- integration into host chromosome

RNA --> DNA (reverse transcription) --> Provirus (integration)

2

Classifications of retroviruses

- Oncoviruses
- Lentiviruses
- Spumaviruses
- Endogenous retroviruses

3

Oncovirus example

Delta: Human T-cell lymphotrophic virus

4

Lentivirus example

HIV

5

Endogenous retrovirus example

HERV-K

6

HERV

- comprises 8-10% of human genome
- derived from persistent infection
- Most HERVs are defective
- Some expected to be associated with human diseases

7

Which HERV types are associated with human dzs?

- HERV-K
- HERV-W

8

What are long terminal repeats LTRs?

cis elements required for:
- reverse transcription
- viral gene transcription
- splicing
- virus integration
- packaging