rEVIEW

Question 1

Opsonization requires

Answer 1

C3b

Question 2

Chemotaxis requires

Answer 2

C3a and C5a

Question 3

Anaphylatoxin requires

Answer 3

C3a and C5a

Question 4

Cytolytic activity requires the MAC components

Answer 4

(C5b-C9)

Question 5

C1-INH

Answer 5

angioedema

Question 6

IL-1
TNF
IL-6
IL-12
Chemokines
IL-10 - Inhibitory

Answer 6

From Antigen presenting cells

Question 7

IFN-gamma

IL-2

Answer 7

Th1 cells

Question 8

IL-4
IL-5
IL-13

Answer 8

Th2 cells

Question 9

IL-17

Answer 9

CD17

Question 10

IL-10

TGF-beta

Answer 10

From Treg cells

Question 11

Expressed only on APC and binds to CD4+

Answer 11

MHCII

Question 12

expressed on all nucleated cells nd binds CD8+ cells

Answer 12

MHCI

Question 13

due to pre-formed antibodies in the recipient against the donor. Takes minutes or hours

Answer 13

Hyperacute rejection

Question 14

due mainly to CMI (both CD4 and CD8 cells) against donor MHC molecules. Also some antibody attack. Takes 10-14 days

Answer 14

Acute Rejection

Question 15

due to CMI and antibody attack

Answer 15

Chronic rejection

Question 16

CD4+ T cells in the graft are activated by allogeneic molecules and produces a

Answer 16

cytokine storm

Question 17

a reaction of donor T-cells against recipient MHC

Answer 17

GVH

Question 18

CD19, CD20, MHC Class I, MHC Class ll and Kappa light chains

Answer 18

B-cell lymphoma

Question 19

2-5 days reaction of a rejection

Answer 19

sensitized–> T-cells activated but no antibodies present

Question 20

. Tumor cells can be destroyed by ____ T-cells that recognize tumor antigen presented by MHC Class l

Answer 20

CD8+

Question 21

releases granzymes and perforins and the Fas-Fas L interaction

Answer 21

T cell

Question 22

CD8 cells are the principal line of defense against:

4

Answer 22

1. virus infected cells
2. intracellular bacteria
3. fungi
4. tumors

Question 23

large, granular lymphocytes

Answer 23

natural killer cells

Question 24

recognize abnormal cells that have lost MHC I

Answer 24

NK cells

Question 25

how do NK cells destroy target cells

Answer 25

with granzymes and perforins

Question 26

occurs 4-8 hours later and is due to eosinophils, neutrophils, T-cells and mononuclear cells, migrating into the area.

Answer 26

Late phase of the acute allergic reaction

Question 27

A speleologist (person who explores caves) is attacked and bitten by a bat. Fearing that the animal may be rabid his physician injects the man with a dose of horse anti-rabies serum. Within 10 minutes he complains of generalized itching, and urticarial wheals (hives) appear on his skin. The most likely cause of this is: A) Circulating immune complex deposition B) An Arthus reaction C) Direct effect of bat saliva on mast cells D) A type II cytotoxic reaction E) IgE-mediated allergic reaction

Answer 27

E) IgE-mediated allergic reaction

Question 28

- antibodies to red cell membranes

Answer 28

Autoimmune hemolytic anemia

Question 29

- antibodies to platelet membrane proteins

Answer 29

Autoimmune thrombocytopenia

Question 30

antibodies to proteins in glomerular basement membrane and alveolar basement membrane

Answer 30

Goodpasture’s syndrome

Question 31

streptococcal antibody cross reacts with a myocardial antigen

Answer 31

Rheumatic fever

Question 32

-antibody to acetylcholine receptor

Answer 32

Myasthenia gravis

Question 33

antibody to the TSH receptor

Answer 33

Graves’ Disease

Question 34

SLE

Answer 34

immune complex disease

Question 35

Bird fancier

Answer 35

Arthus rxn./ localised immune complex and she also has some T-cell infiltration showing Type IV

Question 36

macrophages, dendritic cells, CD4+ and CD8+ T-cells.

Answer 36

Type IV

Question 37

Patch skin test

Answer 37

Type IV

Question 38

RAST test

Answer 38

Type I

Question 39

candida

Answer 39

Type IV

Question 40

``` Dan receives a bone-marrow transplant from an HLA matched brother. This is an example of an Autograft Syngraft Xenograft Allograft ```

Answer 40

Allograft

Question 41

Because although the donor and recipient are matched at the MHC, the donor T-cells must be recognizing some foreign antigen in the recipient.

Answer 41

GVH

Question 42

What is the treatment of GVH

Answer 42

Immunosuppression with drugs such as cyclosporine

Question 43

How can we prevent GVH

Answer 43

Try to remove all the T-cells from the donor bone marrow preparation.

Question 44

Physical exam is remarkable for dry, red patches of skin (eczema) and multiple petechiae (tiny hemorrhagic spots). Lab findings include thrombocytopenia (low platelet count) and reduced IgM levels.

Answer 44

Wiskott-Aldridge Syndrome

Question 45

Which of the following patients would not have increased susceptibility to infection with Mycobacterium tuberculosis? A) Patient with a mutation of the IL-2 receptor B) Patient with a mutation of the IL-12 receptor C) Patient with a mutation of the RAG-1 gene D) Patient with a mutation of the CD 28 gene E) Patient with a mutation of the Btk gene

Answer 45

E) Patient with a mutation of the Btk gene

Question 46

Mutations of the Btk gene are responsible

Answer 46

X-linked agammaglobulinemia.

Question 47

X-linked agammaglobulinemia has normal T-cell function

Answer 47

YEP

Question 48

CD28 competes with

Answer 48

CTL4, an inhibitory receptor

Question 49

T cell regulation

Answer 49

- CTL4 | - PD1