Type II hypertensitivity Flashcards
exam 4
abnormal ab directed against a target organ causes destruction of the target cell by complement mediated lysis or by adcc
type II hypersensitivity
ab coated target cells can also be destroyed by
ab dependent cellular cytotoxicity
autoimmune hemolytic anemia
example of type II
abnormal Ab against the basement membrane of the glomeruli
Goodpasture’s syndrome
_____ is deposited on the BM of the glomeruli and the lung alveoli
IgG
due to abnormal ab to the acetylcholine receptor
myasthenia gravis
myasthenia gravis leads to
impaired muscle contraction
myasthenia gravis and grave’s disease
anti-receptor dx
unregulated overproduction of thyroid hormones of auto-antibody to TSH receptor
Grave’s disease
Ag-Ab complexes are trapped in the small vessels of the body. Binding of complement triggers an inflammatory reaction damaging the vessel walls (vasculitis)
immune-complex disease- Type III
are trapped in the small vessels of the skin, kidney, joints and other sires
immune complexes
are chemotatic for neutrophils
C3a and C5a
neutrophils degranulate in vessel wall releasing
lysosomal enzymes
what do lysosomal granules do?
damage the vessel wall leading to vasculitis
Antigen is DNA and other nuclear components. Antibody is anti-DNA and other antinuclear antibodies (ANA). Complexes are trapped in the small vessels of the skin, kidney and joints
systemic lupus erythematosus (SLE)
neutrophils live for
6 hours
Circulating anti-streptococcal antibodies combine with streptococcal antigen. Complexes are trapped in the glomeruli
post-streptococcal glomerulonephritis
patients treated with serum from an animal such as a horse, will make anti-horse ab
serum sickness
localised immune complex disease
arthus reaction
arthus reaction
appears when antigen is introduced into an individual who already has ab
Farmer’s lung or Bird fancier’s disease
arthus reaction
actinomycete organisms are present in mouldy hay
farmer’s lung
repeated inhalation of actinomycete organisms stimulate systemic
IgG ab production
what happens in farmer’s lung that will make it a type III and type IV
infiltration by T-cells with cytokine production and further inflammation (type IV)
