Rh Blood Group System

Question 1

Rh antibodies were demonstrated by who?

Answer 1

Landsteiner & Weiner

Question 2

RhD and RHCE genes are linked to what chromosome?

Answer 2

Chromosome 1

Question 3

RhAG is found at chromosome ____

Answer 3

Chromosome 6

Question 4

The Rh glycoprotein is made up of _____ amino acids that traverses the plasma membrane ___ times

Answer 4

416

12

Question 5

Rh null individuals suffers a particular RBC morphology abnormality called ____

Answer 5

Stomatocytosis

Question 6

What number is responsble for antigen C and c?

Answer 6

103

Question 7

d antigen denotes what?

Answer 7

Absence of D antigen

Question 8

What is difference between Rh null and Rh-?

Answer 8

Rh null = all genes are absent
Rh- = only D is absent

Question 9

Convert from Fisher-Race to Weiner:

DcE

Answer 9

R²

Question 10

Convert from Fisher-Race to Weiner:

DCE

Answer 10

Rz

Question 11

Convert from Fisher-Race to Weiner:

ce

Answer 11

r

Question 12

Convert from Weiner to Fisher-Race:

ry

Answer 12

CE

Question 13

Convert from Weiner to Fisher-Race:

r²

Answer 13

cE

Question 14

Convert from Fisher-Race to Rosenfield:

DCe/DcE

Answer 14

Rh: 1, 2, 3, 4, 5

Question 15

Convert from Fisher-Race to Rosenfield:

DCe/dce

Answer 15

Rh: 1, 2, -3, 4, 5

Question 16

Why are Rh antigens much more fatal if invovled in Hemolytic Disease of
the Fetus and Newborn?

Answer 16

Mainly because they are well-developed early in the fetal life

Question 17

Why is the first pregnancy safe regarding HDFN?

Answer 17

It is the first time that the mother is exposed to the antigen

Question 18

How immunogenic is the Rh antigen?

Answer 18

It only requires 0.1 mL of Rh positive RBC to stimulate antibody production

Question 19

Rh antibody starts as what type of immunoglobulin?

Answer 19

IgM

Question 20

What is used for detecting the D antigen?

Answer 20

Anti-D

Question 21

Rh antigens are located in the _____

Answer 21

Rh glycoprotein

Question 22

Rh glycoprotein is composed of how many amino acids?

Answer 22

416

Question 23

When an individual has Weak D, is there a of D antigens?

Answer 23

Yes, but it is decreased

Question 24

Weak D was formerly regarded as ____

Answer 24

Du phenotype

Question 25

What are the 3 mechanisms of weak D?

Answer 25

Genetic Weak D
C trans
Partial D (Mosaic D)

Question 26

How are the 3 mdchanisms of Weak D differentiated?

Answer 26

Genetic Weak D - Weak D Test
C trans - Monoclonal reagents
Partial D - Monoclonal and Weak D Test

Question 27

Genetic Weak D is most common among ____.

Answer 27

Blacks

Question 28

Asians are mostly Rh ___.

Answer 28

Positive (+)

Question 29

What test is used to check for genetic Weak D?

Answer 29

Indirect Antiglobulin Test (IAT)

Question 30

Indirect Antiglobulin Test is also known as _____.

Answer 30

Indirect Coombs Test

Question 31

What happens to the RhD and RhCe in Trans position of Weak D?

Answer 31

Opposite to each other

Question 32

Partial D phenotypes should be suspected if:

Answer 32

A D+ individual produces an Anti-D but it doesn’t react with their own RBCs

Question 33

When a Partial D patient is in need of blood transfusion, what blood is going to be used? How about if they are the one donating?

Answer 33

D negative as recipient

D positive as donor

Question 34

IAT is used to detect _____

Answer 34

In vitro sensitization

Question 35

DAT is used to detect ____

Answer 35

In vivo sensitization

Question 36

Coombs check cells are comprised of:

Answer 36

Group O blood
RBCs sensitized with IgG