Rheumatology

Question 1

drugs that may decrease
lacrimal and salivary secretions

Answer 1

diuretics, antihypertensive
drugs, anticholinergics, and antidepressants, should be avoided sojren.

Question 2

Sjögren’s syndrome

Answer 2

Hydroxychloroquine :arthralgias\ mild arthritis.

Question 3

Sarcoidis

Answer 3

• Active may be asymptomatic in up 30%
• ## antiproteinase 3 ANCA >90%.

Question 4

sarcoidosis

Answer 4

hydroxychloroquine: for skin . Minocycline: for cutaneous sarcoidosis.
For pulmonary and other extrapulmonary disease, cytotoxic agents that include methotrexate, azathioprine, leflunomide, mycophe
nolate, and cyclophosphamide are often used.

Question 6

PAN

Answer 6

• Does not involve pulmonary arteries.
• HCV,HBV,Hairy cell leukemia. Deficiency of adenosine deaminase type 2.
• m.c involvment musculoskeletal
• ANCA rarly present
• Hypergammaglobulinemia
• death usually result from GI complication bowel infarct and perforation
• Relapse 10-20%.
• Tx: prednisone and cyclofosfamide

Question 7

AIDS-defining conditions

Answer 7

Kaposi’s sarcoma
non-Hodgkin’s lymphoma,
invasive cervical carcinoma.

Question 8

non-AIDS-defining malignancies

Answer 8

Hodgkin’s disease
multiple myeloma
leukemia;
melanoma;
cervical, brain, testicular, oral,lung, gastric, liver,renal, and anal cancers.

Question 9

Secukinumab

Answer 9

IL -17A
משמש לטיפול ב AS ו Psoriasis