Rheumatology

Question 0

What 2 conditions are associated with anti-U1-RNP antibody?

Answer 0

Mixed connective tissue disease

Systemic lupus erythematous

Question 1

Which 2 endocrine disorders are associated with calcium pyrophosphate disease?

Answer 1

Acromegaly

Hyperparathyroidism

Question 2

What is primary treatment of axial seronegative spondyloarthropathies?

Answer 2

NSAIDS, non biologic DMARDs

Question 3

What 2 conditions are associated with positive p-ANCA?

Answer 3

Microscopic polyangiitis (MPA)
Churg-Strauss syndrome

Question 4

What is the rheumatologic condition associated with chondrocalcinosis of the knees, shoulders, wrists, and pubic symphysis?

Answer 4

Calcium pyrophosphate deposition disease

Question 5

What dose of chronic steroids is associated with increased risk of osteoporosis?

Answer 5

> 7.5 mg PO daily x 3 months

Question 6

Which are 4 DMARDs that have high risk of teratogenicity and should always be avoided in pregnancy if at all possible?

Answer 6

Methotrexate
Leflunomide
Cyclophosphamide
Mycophenilate mofetil

Question 7

What drug can be given to speed removal of leflunomide from the body?

Answer 7

Cholestyramine TID x 8 days

Question 8

What enzyme level should be checked prior to initiation of azathioprine?

Answer 8

TPMT level

Question 9

What rare, severe neurological disorder can be seen with rituximab infusions?

Answer 9

Progressive multi focal leukoencephalopathy/JC virus

Question 10

What condition is belimumab (anti-BAFF monoclonal antibody) used to treat?

Answer 10

SLE

Question 11

Which urate lowering agent helps with under excretors of urate in the kidney?

Answer 11

Probenecid- avoid if history or kidney stones or tophaceous gout

Question 12

Which inflammatory myositis more commonly involves distal muscle groups?

Answer 12

Inclusion body myositis

Question 13

Is limited or diffuse cutaneous systemic sclerosis more likely to develop PAH?

Answer 13

Limited (including CREST syndrome)

Question 14

What complication can occur if patients with scleroderma are given oral corticosteroids?

Answer 14

Can potentially precipitate scleroderma renal crisis

Question 15

What is common triad of scleroderma renal crisis?

Answer 15

Sudden onset hypertension, azotemia, and microangiopathic hemolytic anemia - treat with ACEI

Question 16

What is main treatment of ILD in scleroderma?

Answer 16

Cyclophosphamide

Question 17

What is main treatment of skin/joint symptoms in scleroderma?

Answer 17

Methotrexate

Question 18

Which antibody titer in scleroderma is most associated with development of ILD?

Answer 18

Anti-Scl-70

Question 19

What scleroderma spectrum disorder spares the digits and face?

Answer 19

Eosinophilic fasciitis

Question 20

What malignancy are patients with Sjogren’s at increased risk (44x more likely) to get?

Answer 20

Lymphoma or MALToma

Question 21

What is the most frequent cardiac manifestation of mixed connective tissue disease?

Answer 21

Pericardial effusion

Question 22

What is treatment of PAH in setting of MCTD?

Answer 22

Cyclophosphamide

Question 23

Which blood pressure medications can precipitate gout attacks?

Answer 23

Thiazides and loop diuretics

Question 24

What condition has positively birefringint rhomboid crystals?

Answer 24

Calcium pyrophosphate deposition disease (pseudogout)

Question 25

Which type of myositis commonly has dysphagia associated with it?

Answer 25

Inclusion body myositis

Question 26

What concurrent disease is more likely to cause Kawasaki disease in adults?

Answer 26

HIV

Question 27

Which HLA is associated with Bechet disease?

Answer 27

HLA B51

Question 28

What disorder presents with recurrent swelling and pain of the external ear?

Answer 28

Relapsing polychondritis

Question 29

How often are fevers in adult onset Stills disease?

Answer 29

Quotidian aka daily

Question 30

What color is rash in adult onset stills disease?

Answer 30

Salmon colored

Question 31

What lab level can help diagnose adult onset stills disease?

Answer 31

Extremely elevated ferritin >1000

Question 32

What complication are patients with familial Mediterranean fever at risk to develop?

Answer 32

Amyloidosis

Question 33

How often are fevers in FMF?

Answer 33

Every 12-72 hrs

Question 34

What is the 1st and 2nd treatments for axial involvement in seronegative spondyloarthropathies?

Answer 34

1 -NSAIDS | 2- TNFa inhibitors

Question 35

Which TNFa inhibitor should not be used for IBD associated arthritis?

Answer 35

Etanercept

Question 36

What crystal disorder presents usually in setting of trauma with joint effusion but the crystals cannot be seen under polarized light?

Answer 36

Basic calcium phosphate deposition disease (requires alizarin stain to see crystals)

Question 37

What underlying malignancy may be associated with HSP in adults?

Answer 37

MDS