Rheumatology Antibodies

Question 1

Anti-cyclic citrullinated peptide (anti-CCP)

Answer 1

Rheumatoid arthritis

Question 2

Anti-centromere

Answer 2

CREST syndrome (limited SS)

Question 3

Anti-Jo-1

Answer 3

Polymyositis/dermatomyositis

Question 4

Anti-Scl70 (anti-DNA topoisomerase)

Answer 4

SS (diffuse)

Question 5

Anti-U3 RNP (anti-RNA polymerase)

Answer 5

SS (especially with renal crisis)

Question 6

Anti-U1 RNP

Answer 6

Mixed connective tissue disease

Question 7

Anti-Smith

Answer 7

Lupus

Question 8

Anti-dsDNA

Answer 8

Lupus

Question 9

Anti-nuclear (ANA)

Answer 9

Lupus

lots of others

Question 10

Anti-Ro (Anti-SSA)

Answer 10

Sjogren syndrome
Neonatal lupus
Subcutaneous lupus

Question 11

Anti-La (Anti-SSB)

Answer 11

Sjogren syndrome
Neonatal lupus
Subcutaneous lupus

Question 12

Anti-myeloperoxidase

(= perinuclear anti-neutrophil cytoplasmic, P-ANCA

Answer 12

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg Strauss)

Question 13

Anti-proteinase-3 (= diffuse cytoplasmic

anti-neutrophil cytoplasmic, C-ANCA)

Answer 13

Granulomatosis with polyangiitis (Wegener’s)