Rheumatology: Autoimmunity/ Systemic Lupus Erythematosus Flashcards Preview

Blood and Lymph Unit 3 > Rheumatology: Autoimmunity/ Systemic Lupus Erythematosus > Flashcards

Flashcards in Rheumatology: Autoimmunity/ Systemic Lupus Erythematosus Deck (16)
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What are two examples of organ specific autoimmunity?

1. Goodpastures
2. Myasthenia gravis


What is an example of systemic autoimmunity?

Systemic lupus erythmatosus


What type of immunopathology is characterized by systemic lupus erythmatosus?

Type II AND Type III


Name the criteria for the diagnosis of systemic lupus erythmatosus..

1. Malar rash
2. Discoid rash
3. Photosensitivity
4. Oral ulcers
5. Arthritis
6. Serositis
7. Renal involvement
8. CNS involvement (seizures or psychosis)
9. Hematologic disorders
10. Immunologic
11. Antinuclear antibodies


How many of the diagnostic criteria does a patient need to meet in order to be diagnosed with SLE?

4 out of 11


Does SLE effect more men or women?



What ethnicity does SLE effect more often?

African Americans and Hispanics


What are the genetic predisposing factors associated with SLE?

HLA-DR3 and C4A null alleles


What is upregulated in SLE?

INF-alpha and INF-beta it is called "INF Signature"


When is the onset of women with SLE?

Childbearing years


What are two environmental factors that affect SLE?

1. Hormones
--Estrogen: accelerating disease
--Androgens: protective

2. Sun Exposure
--UV light > Keratinocytes > Cytokines > Increased antibody release


What are three specific antibody-mediated manifestations in SLE?

1. Hemolytic anemia
2. Anti-Phospholipid Antibodies
3. CNS Manifestations


Describe the process of hemolytic anemia seen in patients with systemic lupus erythmatosus.

Autoantibodies to red blood > Recruitment of complement > Destruction in the reiculoendothelial system


What does anti-phospholipid antibodies cause increased or decreased clotting?

Kind of both.
-Block prothrombin activation (clotting) elevated PTT

-But then increased clotting leading to thrombosis


Name some of the CNS manifestations seen in type II SLE.

What percentage of patients with SLE have CNS manifestations?

Anti-neuronal antibodies- depression, cognitive dysfuction, psychosis, seizures

Stroke or chorea due to vascular ischemia from vasculitis and thrombosis

66% of patients with SLE


Describe the manifestation of type III SLE.

Lupus glomerulonephritis.
Nearly all patients have some form of kidney involvement
Immune complexes deposit in kidney and recruit complement
IgG - Double stranded DNA complex