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Medicine > Rheumatology - Polymyositis and Dermatomyositis > Flashcards

Rheumatology - Polymyositis and Dermatomyositis Flashcards

1
Q

What are polymyositis and dermatomyositis?

A

Autoimmune disorders causing muscle inflammation

Causing proximal muscle weakness

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2
Q

What is also present with dermatomyositis?

A

Skin changes

Gottron papules
Heliotrope rash
Periorbital oedema
Photosensitive erythematous rash on back, shoulders and neck

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3
Q

What can cause poly/dermatomyositis?

A

Cancer (makes them paraneoplastic syndromes)

Coxsackie virus
HIV
HLA genes

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4
Q

What test is used for myositis?

A

Creatine kinase

Inflammation of muscle cells releases CK

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5
Q

What can caused raised creatine kinase?

A

Myositis
Rhabdomyolysis
AKI
MI
Statins
Strenuous exercise

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6
Q

What is the most common antibody associated with polymyositis?

A

Anti-Jo-1 antibodies

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7
Q

How is myositis managed?

A

Assess for possible underlying cancer

Phyisotherapy
Occupational therapy
Corticosteroids first-line

Immunosuppressants, biologics second-line

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