Riggs et al (2007) - Combined biological and CBT

Question 1

Aim

Answer 1

To evaluate the effect of fluoxetine vs placebo in combination with CBT on depression, substance abuse disorder, and conduct disorder.

Question 2

Method

Answer 2

IMD - randomised controlled study.

Question 3

Participants

Answer 3

126 adolescents with diagnosed depression, substance abuse disorder, and conduct disorder.

Question 4

Procedure

Answer 4

16 weeks being treated with either:

Fluoxetine/placebo and a course of CBT directed at dealing with substance abuse.

Question 5

Results

Answer 5

Combination of fluoxetine and CBT may be the most effective option as it led to significant improvements on one measure of depression in comparison with CBT and placebo.

Question 6

Conclusion

Answer 6

Fluoxetine combined with CBT may have similar safety and efficacy for depression in adolescents with active substance abuse disorder to that reported for depressed adolescents without substance abuse disorder.