Robbins Review Q's

Question 1

Perivascular accumulationof T cells, particularly CD4+ cells, is typical of what type of hypersensitivity?

Driven by _______ response mediated largely by the release of _____.

Answer 1

• Delayed (type IV) hypersensitivity skin rxn
• Drive by T_H1 response mediated largely by the release of IL-2.

Question 2

Arthus rxn + serum sickness are examples of what type of hypersensitivity?

Answer 2

• Type III hypersensitvity
• Often exhibit vasculitis

Question 3

Defective clearance and increased burden of nuclear apoptotic bodies is considered a fundamental mechanism underlying which autoimmune disease?

Answer 3

SLE

Question 4

Hemolytic anemia, cytopenias, leukopenias, thrombocytopenias, and other anemias are all commonly seen in which autoimmune disease?

Answer 4

SLE

Question 5

Wire loop glomerular capillary lesions are characteristic of?

Answer 5

Lupus nephritis

Question 6

Anti-U1-RNP are found in?

Answer 6

Mixed CT disease

Question 7

Anti-Jo-1 antibody specific for?

Answer 7

Polymyositis/dermatomyositis

Question 8

Antihistone antibodies are present in many cases of?

Answer 8

Drug-induced SLE

Question 9

Granulomatous inflammation and T cell cytotoxicity are features of what type of hypersensitivity?

Answer 9

Type IV

Question 10

Esophageal dysmotility is a feature of which autoimmune disease?

Answer 10

Scleroderma

Question 11

What is the most serious condition likely to occur in a patient with Sjorgen Syndrome?

Answer 11

B cell lymphoid malignancies, MALT lymphoma = Non-Hodgkin lymphoma

Question 12

anti-DNA topoisomerase most often seen with what condition?

Answer 12

Diffuse systemic sclerosis

Question 13

Malignant hypertension is a serious complication seen in patients with what autoimmune disease?

Answer 13

Diffuse systemic sclerosis (scleroderma)

Question 14

Low back pain from sacroiliitis and a positive serology for HLA-B27 are characteristics of?

Answer 14

Ankylosing spondylitis

Question 15

A 44 yo woman has had tightening of the skin of her fingers for the past 2 years, making them difficult to bend. She has had increasing difficulty swallowing for the past 8 months. She is suffering from Raynauds phenomenon. On PE the skin on her face, neck, hands, and forearm appear firm and shiny. Her BP is 200/130 mm Hg. She has prominent interstitial markings on chest radiograph, and lung function tests indicate moderately severe restrictive pulmonary disease. Which condition is she most likely to have?

Answer 15

Diffuse systemic sclerosis (scleroderma)

Question 16

Which dermal inflammatory cells are the initiators of the skin problems seen in systemic sclerosis (including extensive dermal fibrosis and sclerodactyly)?

Activate which cells?

Answer 16

• CD4+ cells initiate
• Activate macrophages and mast cells

Question 17

What is the pattern of muscle weakness in polymyositis?

Which lymphocytes involved?

Additional complications of this disease?

Answer 17

• Tend to be symmetric and affect proximal musculature first
• CD8+ cells
• Myocarditis, vasculitis, and pneumonitis

Question 18

Fibrinoid necrosis and thrombosis are typical of what kind of rejection?

Answer 18

Hyperacute rejections

Question 19

Damage to tubular epithelium by direct cytotoxicity and by release of cytokines, such as IFN-gamma, which activate macrophages are characteristic of what kind of rejections?

Answer 19

Acute cellular rejections

Question 20

X-linked form of SCID deficiency in?

AR from of SCID deficiency in?

Answer 20

X-linked = common y-chain, part of many cytokine receptors

Autosomal recessive = defect in gene encoding adenosine deaminase

Question 21

Lack of isotype switching, particular susceptibility to pneumocystis, and abnormal CD40-CD40L interactions characteristic of?

Answer 21

Hyper-IgM syndrome

Question 22

Which X-linked disorder is characterized by thrombocytopenia, eczema, decreases IgM, and sometimes increased IgA?

Increased risk for infections by?

Answer 22

• Wiskott-Aldrich syndrome
• Pneumocystis jiroveci

Question 23

Which 3 cell types carry HIV infection?

Answer 23

1) DCs (langerhans cells in epithelium and follicular DCs in LNs)
2) Monocytes-macrophages
3) CD4+ T cells

Question 24

Plaque-like nodular reddish purple lesions in patient with HIV infection is associated with?

Answer 24

• Kaposi Sarcoma associated with:
• Human herpesvirus-8 (HHV-8)

Question 25

Chronic inflammatory conditions, such as rheumatic fever, ankylosing spondylitis, and systemic sclerosis, all may result in amyloidosis of what type?

Answer 25

AA amyloid - derived from SAA (acute phase reactant)

Question 26

Positive test for Bence Jones proteins, increasing malaise and back pain, mild muscle wasting, and a radiograph of spine showing rounded lucent lesions are characteristic of what underlying condition?

What type of Amyloid deposit?

Answer 26

• Multiple myeloma
• AL amyloid