Perivascular accumulationof T cells, particularly CD4+ cells, is typical of what type of hypersensitivity?
Driven by _______ response mediated largely by the release of _____.
- Delayed (type IV) hypersensitivity skin rxn
- Drive by TH1 response mediated largely by the release of IL-2.
Arthus rxn + serum sickness are examples of what type of hypersensitivity?
- Type III hypersensitvity
- Often exhibit vasculitis
Defective clearance and increased burden of nuclear apoptotic bodies is considered a fundamental mechanism underlying which autoimmune disease?
Hemolytic anemia, cytopenias, leukopenias, thrombocytopenias, and other anemias are all commonly seen in which autoimmune disease?
Wire loop glomerular capillary lesions are characteristic of?
Anti-U1-RNP are found in?
Mixed CT disease
Anti-Jo-1 antibody specific for?
Antihistone antibodies are present in many cases of?
Granulomatous inflammation and T cell cytotoxicity are features of what type of hypersensitivity?
Esophageal dysmotility is a feature of which autoimmune disease?
What is the most serious condition likely to occur in a patient with Sjorgen Syndrome?
B cell lymphoid malignancies, MALT lymphoma = Non-Hodgkin lymphoma
anti-DNA topoisomerase most often seen with what condition?
Diffuse systemic sclerosis
Malignant hypertension is a serious complication seen in patients with what autoimmune disease?
Diffuse systemic sclerosis (scleroderma)
Low back pain from sacroiliitis and a positive serology for HLA-B27 are characteristics of?
A 44 yo woman has had tightening of the skin of her fingers for the past 2 years, making them difficult to bend. She has had increasing difficulty swallowing for the past 8 months. She is suffering from Raynauds phenomenon. On PE the skin on her face, neck, hands, and forearm appear firm and shiny. Her BP is 200/130 mm Hg. She has prominent interstitial markings on chest radiograph, and lung function tests indicate moderately severe restrictive pulmonary disease. Which condition is she most likely to have?
Diffuse systemic sclerosis (scleroderma)
Which dermal inflammatory cells are the initiators of the skin problems seen in systemic sclerosis (including extensive dermal fibrosis and sclerodactyly)?
Activate which cells?
- CD4+ cells initiate
- Activate macrophages and mast cells
What is the pattern of muscle weakness in polymyositis?
Which lymphocytes involved?
Additional complications of this disease?
- Tend to be symmetric and affect proximal musculature first
- CD8+ cells
- Myocarditis, vasculitis, and pneumonitis
Fibrinoid necrosis and thrombosis are typical of what kind of rejection?
Damage to tubular epithelium by direct cytotoxicity and by release of cytokines, such as IFN-gamma, which activate macrophages are characteristic of what kind of rejections?
Acute cellular rejections
X-linked form of SCID deficiency in?
AR from of SCID deficiency in?
X-linked = common y-chain, part of many cytokine receptors
Autosomal recessive = defect in gene encoding adenosine deaminase
Lack of isotype switching, particular susceptibility to pneumocystis, and abnormal CD40-CD40L interactions characteristic of?
Which X-linked disorder is characterized by thrombocytopenia, eczema, decreases IgM, and sometimes increased IgA?
Increased risk for infections by?
- Wiskott-Aldrich syndrome
- Pneumocystis jiroveci
Which 3 cell types carry HIV infection?
1) DCs (langerhans cells in epithelium and follicular DCs in LNs)
3) CD4+ T cells
Plaque-like nodular reddish purple lesions in patient with HIV infection is associated with?
- Kaposi Sarcoma associated with:
- Human herpesvirus-8 (HHV-8)
Chronic inflammatory conditions, such as rheumatic fever, ankylosing spondylitis, and systemic sclerosis, all may result in amyloidosis of what type?
AA amyloid - derived from SAA (acute phase reactant)
Positive test for Bence Jones proteins, increasing malaise and back pain, mild muscle wasting, and a radiograph of spine showing rounded lucent lesions are characteristic of what underlying condition?
What type of Amyloid deposit?
- Multiple myeloma
- AL amyloid