Rodriguez Adrenergic antagonists

Question 1

What reactions do B1 adrenoreceptors do?

Answer 1

1) tachycardia
2) increased myocardial contractility
3) increased lipolysis

Question 2

What do B2 adrenorecptors do?

Answer 2

1) Vasodilation
2) slight decrease in peripheral resistance
3) bronchodilation
4) increased glycogenolysis ( liver and muscle)
5) increased Glucagon release
6) relaxation of uterine smooth muscle

Question 3

How is the ciliary body effected by post-ganglionic sympathetic activity?

Answer 3

1) There are mainly B2 receptors in the stroma and epithelia of ciliary body.
2) there are a2 recpetors at eh non-pigmented epithelium
3) adrenergic stimulation causes ciliary muscle relaxation -but is not clinically significant.
4) a receptor stimulation at the non-pigmented epithelium produces an inhibitory response, causing a decrease in aqueous production

Question 4

What are B adrenoreceptor antagonists?

Answer 4

1) b blockers
2) inhibit catecholamines reversibly
3) cardio selective
4) ocular hypotensive drug

Question 5

How do B blockers work?

Answer 5

block the production of aqueous humor on non pigmented epithelium.
Also causes vasoconstriction on CB vessels.

Question 6

Timolol Maleate

Answer 6

non-cardioselective b-blocker

2) negative sympathomimetic activity
3) concentrations come in 0.25% and 0.5%

Question 7

What does Timolol maleate act on?

Answer 7

the ciliary body

> B2 adrenoreceptors and some B1.

Question 8

How much does Timolol decrease IOP by?

Answer 8

20-30%

Aprox: 7mmHg

Question 9

Timolol administration

Answer 9

1 drop BID or 1 drop d
Max effect achieved after 3 weeks.
It has a contralateral effect.
must be applied in the morning.

Question 10

Clinical uses of Timolol

Answer 10

1) Primary Open angle glaucoma.
2) Ocular hypertension
3) Pre and Post surgery

Question 11

What is an ocularhypotension drug that can be used before and after surgery?

Answer 11

timolol

Question 12

What are the OCULAR side effects of Timolol

Answer 12

1) Blepharo conjunctivitis : Erythema and edema
2) Decreased corneal sensitivity
3) Dry Eye: Superficial punctate keratopathy

Question 13

What are the systemic side effects of Timolol?

Answer 13

– Bradycardia
– Systemic hypotension
– CHF
– Heart block
– Bronchospasm
– Diarrhea
– Amnesia
– Elderly	special	consideration
– Hypoglycemia
– Alteration lipid plasma	profile

Question 14

Contraindications of TImolol

Answer 14

• • Bronchial asthma
• • COPD
• • Bradycardia
• • Severe heart block
• • Overt Cardiac Failure
• • Children and infants