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Round 3 Flashcards

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1
Q

What is the Schizophrenia prevalence in the general population?

A

0.5%-1%

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2
Q

What is the Schizophrenia prevalence for a sibling?

A

10%

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3
Q

What is the Schizophrenia prevalence for a monozygotic twin?

A

50%

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4
Q

What drug is purple gray metallic rash over sun exposed areas and jaundice?

A

Chlorpromazine

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5
Q

What drug is prolonged QTc and pigmented retinopathy?

A

Thioridazine

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6
Q

If a patient has drug induced Parkinsonism, what do you not give?

A

L-Dopa

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7
Q

What is the incidence of bipolar in the general population?

A

1%

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8
Q

What is the incidence of bipolar in a brother who’s brother has bipolar?

A

80-90%

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9
Q

What stroke would cause bipolar in an older adult?

A

Right Frontal Hemisphere stroke

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10
Q

Possible EKG signs of Lithium?

A

T-wave flattening and U-waves

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11
Q

What is the atypical agent with highest risk of EPS and increased prolactin?

A

Risperidone

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12
Q

What atypical is weight neutral but prolongs QTc, anti-psychotic?

A

Ziprazodone

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13
Q

What atypical is weight neutral but increases akathisia?

A

Aripiprazole

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14
Q

Which atypical agent is associated with weight gain?

A

Olanzapine

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15
Q

Which anti-psychotic can cause orthostasis and cataracts?

A

Quietiapine (alpha blocking properties)

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16
Q

What are the two lab values to worry about for clozapine?

A

WBC less than 3000 and ANC less than 1500

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17
Q

What sex based thing can SSRIs be used for?

A

Premature Ejaculation

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18
Q

What three drugs can really cause depression?

A

IFN-gamma, methyl-dopa, and Beta Blockers

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19
Q

Left Middle Cerebral Artery, what can that cause?

A

Depression

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20
Q

What SSRI has the most drug-drug interactions?

A

Paroxetine

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21
Q

What SSRI do you not have to taper, due to a short half life?

A

Fluoxetine

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22
Q

What SSRI has the fewest drug-drug interactions?

A

Citalopram

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23
Q

What is the rationale for depression and sleep issues?

A

Depression decreases REM latency, the faster I get into REM the more REM I have, and the less rested, I am

Your body rests best not in REM, slow wave sleep

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24
Q

SSRI discontinuation syndrome, what is the most common drug that can cause it? Name 2

A

Sertraline and Fluvoxamine

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25
What can you not give bupropion too?
Alcoholics, Bulimia, and Epileptics
26
Venlafaxine is bad for what type of patients? Particularly with St. John's wort
Hypertension patients
27
Hypertensive crisis with MAOi, what do I use?
Phentolamine 5 mg
28
What is leaden paralysis in the morning, sleeping more and gaining weight? How is it best treated?
Atypical Depression, can affect social functioning Treated best with MAOi
29
Children, age 1-3, what are they big for?
Object Permanence, objects are there even when they cannot be seen
30
Children, age 3-5, what are they big for?
Pre-operational egocentric, child can only understand his perspective, not another perspective
31
Children, age 6-11, what are they big for?
Concrete Operational, death is permanent
32
Children, age 11 and above, what are they big for?
Children can learn to think abstractively
33
Macrocephaly, long face, and macroorchism, young child, mentally handicapped, what is this?
Fragile X
34
Café-au-laitspots, seizures large head. Autosomal dominant
Neurofibromatosis
35
Coarse facies, short stature, cloudy cornea. Autosomal recessive.
Hurler Syndrome
36
Broad, square face, short stature, self-injurious behavior. Deletion on Chr17
Smith Magenis
37
Hypotonia, hypogonadism, hyperphagia, skin picking, agression. Deletion on paternal Chr15.
Prader-Willi
38
Seizures, strabismus, sociable w/ episodic laughter. Deletion on maternal Chr15.
Angelman
39
Elfin-appearance, friendly, increased empathy and verbal reasoning ability. Deletion on Chr7.
Williams
40
ADHD-like sxs, microcephaly, smooth philtrum. Most common cause of mental retardation.
Fetal Alcohol Syndrome
41
Seizures, chorioretinitis, hearing impairments, periventricular calcifications, petechiae@ birth, hepatitis.
Congenital CMV infection.
42
Seizures, hearing impairments, cloudy cornea/retinitis, heart defects, low birth weight.
Congenital Rubella Syndrome
43
Abnormal muscle tone, unsteady gait, seizures, mental retardation or learning disability.
Cerebral Palsy from birth asphyxia.
44
IUGR, hypertonia, distinctive facies, limb malformation, self-injurious behavior, hyperactive.
Cornelia de Lange
45
Coloboma, heart defects, choanal atresia, growth retardation, GU anomalies, ear deformity and deafness. Chr8.
Charge Syndrome
46
Autism spectrum sxs, heart disease, palate defects, hypopastic thymus, hypoCa. Chr22 deletion.
DiGeorge Syndrome
47
Vomiting, seizures, lethargy, coma. Acidosis w/ stress, illness. Causes neurological damage.
Maple Syrup Urine Disease
48
Exclusively in girls, normal development for 6-8mo, then regression, handwringing, loss of speech and use of hands. X-linked dominant deletion of MECP2.
Rett Syndrome
49
Normal development until age 2 then major loss of verbal, social skills w/ autistic like behavior.
Childhood Disintegrative Disorder
50
Lack of mother-child eye contact, language delay/repetitive language, pre-occupation w/ “parts of toys” before age 3.
Autism
51
Problems with social skills (usually recognized in preschool) w/ reserved verbal ability.
Asperger
52
Methylphenidate, what is the MOA? What disease is it used in?
Blocks DA reuptake ADHD
53
Amphetamine, what is the MOA? What disease is it used in?
Blocks DA/NE reuptake ADHD
54
Atomoxetine, what is the MOA? What disease is it used in?
NE reuptake inhibitor Non stimulant****** ADHD
55
Clonidine, Guanfacine, what is the MOA? What disease is it used in?
Alpha 2 agonists, reduce peripheral SNS ADHD
56
Tic disorder, what is the first line drug? What is most effective?
Clonidine Haloperidol/Pimozide Dopamine Receptor Antagonists
57
7 year old complains of frequent abdominal pain resulting in many missed school days. He never gets the pain on the weekends or in the summer. What disorder is this?
Separation Anxiety Disorder
58
6 year old adopted child is brought in because she has not formed a relationship with her adoptive parents. She is inhibited and hyper vigilant. What disorder is this?
Reactive Attachment Disorder
59
An 18mo old baby has recently been regurgitating and re-chewing her food. She had previously been eating normally. What disorder is this?
Rumination Disorder
60
Patient has dementia, motor dysfunction, and dysarthria, what disease is this? What is the anatomical problem?
Marchiafava-Bignami Disease Corpus Callosum problem, and surrounding white matter problems Chronic Alcohol use induced
61
What is a disorder of anterograde amnesia, disorientation that lasts less than a day, is reversible, and is not associated with a comorbidity?
Transient Global Amnesia
62
Dissociative Amnesia usually involves what?
Trauma to the person, has to go past more than the event itself
63
How long do we need illness anxiety disorder to make this a thing?
6 months
64
What is low in CSF that is increased with aggression and impulsiveness?
Serotonin
65
If I was going to win a long time Benzo, what would I most likely have?
Insomnia
66
What is the DOC for narcolepsy?
Sodium Oxybate
67
What is used for RLS?
Dopamine agonists and Benzodiazepines
68
How long should I wait after an MAOi to use an SSRI?
2 weeks
69
Which SSRI is most likely to cause weight gain?
Paroxetine
70
What pathway is positive symptoms?
Mesolimbic
71
What pathway is negative symptoms?
Mesocortical
72
What is lamotrigine used for?
Bipolar Depression
73
What is the not so good side effect of Amitriptyline?
Visual hallucinations
74
When I have fast EEG activity, what do I have?
Delirium Tremens
75
When I have delirium from too many girl scout cookies, what does my EEG look like?
Diffuse Background on EEG
76
What patients are very sensitive to EPS symptoms and should not be given anti-psychotics?
Lewy Body Dementia
77
What is the strong emotional reaction patients may experience when retrieving traumatic memories?
Abreaction

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