S63(1) - Drug Screen

Question 1

Behaviors associated with use of drugs of abuse.

Answer 1

Persons who claim multiple drug “allergies.”
Controlled substance Hx. of use or abuse.
Persons who refuse the test.
Repeatedly losing prescriptions for controlled substances.

Question 2

Collection of split samples in sealed tamper-resistant containers.

Answer 2

Sample size > 30 mL
Temperature 90F - 100F.
Urine pH of 4.5 to 8.5.
Chain of custody tracking for specimen handling for collection to assay.

Question 3

EI is the most common assay method.

Gas chromatography-mass spectrometry (GC-MS) is used for confirmation. Takes more time.

Answer 3

true

Question 4

Federal (DHHS) guidelines for the workplace tests for these agents:

Answer 4

marijuana; 
cocaine; 
opiates; 
PCP; 
amphetamines; and 
methamphetamine.

Question 5

EI that Falls Short
Measures d-amphetamine and d-methamphetamine.
Unable to detect MDMA and MDA.

Answer 5

Many drugs false (+): selegine, bupropion, pseudoephedrine, metformin, and etc…

Question 6

EI that Falls Short
Benzodiazepines – many types.
Measures nordiazepam and oxazepam.
Does NOT detect other benzos.

Answer 6

False positive (+): sertraline, efavirenz

Question 7

EI that Falls Short

Opiates – tested agents are morphine and codeine

Answer 7

False (+): fluoroquinolones, naltrexone, poppy seeds.

Methadone: not detected.

Question 8

EI that Falls Short
PCP:
Many false (+): venlafaxine, O-desmethylvenlafaxine, ibuprofen, diphenhydramine, lamotrigine, zolpidem

Answer 8

True

Question 9

Marijuana – measures metabolite 9-carboxy THC

Answer 9

False (+): efavirenz, ibuprofen, naproxen.

Question 10

Hair is stable tissue less affected by adulterants.

Can detect drugs after weeks or months.

Answer 10

true

Question 11

What is the most common assay method used for urine drug screens?

Answer 11

Enzyme Immunoassay (EI).

Question 12

Are all drugs of abuse tested when undergoing a urine drug screen?

Answer 12

NO… that can be good or bad

Question 13

Should pseudoephedrine is included in a urine drug screen?

Answer 13

Yes… amphetamine screen (methamphetamine – remember how it’s made)