Safe Transfusion Practice Flashcards
What is the BSQR Act (2005)?
Blood Safety and Quality Regulations Act
- sets standards for quality and safety of human blood and blood components
- includes training, administration, traceability requirements and notification of adverse reactions and events
- governed by the Medical Health Care Regulatory Agency (MHRA)
- must comply with act 100% of time
Patient Blood Management (PBM) is an evidence based multidisciplinary approach to optimising the care of patients who may need a blood transfusion. What does it include?
Patient and staff education
Active management of anaemia
Minimise the volume of blood samples taken
Use restrictive thresholds
One unit transfusion in non bleeding patients then reassess
Active management of abnormal haemostasis
Use alternatives to transfusion where appropriate
Surgical patients: detect and treat anaemia pre op, be aware of drug interactions that increase anaemia risk
Transfusion incidents and reactions are reported to what 2 external agencies?
MHRA/SABRE - legal reporting system
SHOT - voluntary BUT required by CQC/NHSLA
What is a never event?
Transfusion of ABO incompatible blood components
What is the most common cause of death and major morbidity (with regards to transfusions)?
Transfusion associated circulatory overload (TACO)
What were the highlights of the SHOT report 2016?
Human factor played a part in 87% of reports to SHOT
TACO = most common cause of death
Number of reports of delayed transfusion has increased
Missed specific requirements (irradiated blood products, CMV neg) continues to be leading cause of patients not receiving the correct components
What are the indications for gamma irradiated blood components?
Patients treated with certain chemotherapy drugs e.g Alemtuzumab, Bendamustine, Fludarabine
Hodgkin’s disease - indefinitely from time of diagnosis
Intrauterine transfusions
What do irradiated blood products reduce the risk of?
Graft vs host disease in at risk population
- destroys any T lymphocytes remaining in donated blood
What are the indications for CMV seronegative blood components?
All pregnant mothers until establish labour
Intrauterine transfusion
Neonates
What are the indications for HLA- matched platelets?
If patient has poor response to 2 or more platelet transfusions
What are the indications for HbS negative RBCs?
Patients with sickle cell disease
Infants up to 1 year of age
Where CMV status is unknown what should you assume?
The patient is CMV neg
What is the irradiation indicator on the RADTAG labels?
If central dot white = not irradiated
If central dot blue = irradiated
What does a group and save determine?
Patient’s blood group and rhesus status
Screens for atypical antibodies
How long is a group and save valid for?
Maximum of 3 days
How long does a group and save take?
Approximately 40 minutes
Is blood issued with a group and save?
No
It is done if blood loss not anticipated, but maybe required if loss more than expected
How many group and save samples are needed?
2 separate group and save results required before blood can be issued.
G&S sample 1 - results can be used from past 10 years
G&S sample 2 - must be current (max 3 days)
What should you do if you are unsure if you need to take 1 or 2 samples from patient for G&S?
Phone/ bleep blood bank
What is a crossmatch?
Physically mixing patient’s blood with donor’s blood to see if immune reaction occurs
In general should second sample for GandS be taken at same or different time as first?
Different time
BUT in life threatening emergency (major haemorrhage) two samples may be drawn from same venepuncture provided: two trained and competent members or staff independently positively identify patient, witness the blood drawn and independently label and sign the sample and request forms
The decision to transfuse should be based on…
Careful assessment of patient’s clinical state and must be justified as essential to prevent major morbidity and mortality
What general principles should prescribing clinicians follow when deciding to transfuse?
Consider all alternatives before prescribing blood products
Discuss risk and benefits
Provide written patient information leaflets
Document consent on prescription or in medical notes
Inform patient they can no longer be blood donor
All patients should be assessed for their risk of TACO. This should include…
Consideration of their weight Review med history (especially cardiac and respiratory) Review of fluid balance Consider infusion rates Consider need for diuretics Consider one unit transfusions Review of patient in between units Add to fluid balance chart
This assessment should be documented in patient notes