Sahay Flashcards
(25 cards)
Define absorption
When a drug is released from its formulation/administration site and enters the bloodstream
Define distribution
The movement of a drug in the bloodstream
Define metabolism
A process through which the drug is biochemically modified usually through specialized enzymatic systems
Define excretion
Getting rid of the drug byproduct
Define pharmacokinetics
Movement of the drug in the body or the study of the time course of absorption, distribution, metabolism, and excretion of drugs from biological systems
Define pharmacodynamics
Power of the drug in the body
What are the four parts of pharmacokinetics?
Absorption, distribution, metabolism, excretion
What are two parts of pharmacodynamics?
Drug-receptor interactions and potency/efficacy
What is elimination?
Metabolism and excretion
What is one of the major considerations that account for absorption of a drug?
Route of administration
Where is the major site for drug metabolism?
The liver
Where is the major site for drug excretion?
The kidney
How does metabolism usually affect a drug?
Makes it more hydrophilic
Define bioavailability
The rate and extent to which an active drug ingredient or therapeutic moiety is absorbed from a drug product and becomes available at the site of action
Define bioequivalence
The comparison of bioavailabilities of different formulations, drug products, or batches of the same drug product
Define MEC
Minimum effective concentration - below there is no effect
Define MTC
Maximum tolerated concentration - above is toxic
Define AUC
Area under curve - shows drug absorption/elimination over time
Define onset time
The amount of time until the drug starts to work
Define intensity
The maximum concentration reached
Define duration of action
The amount of time the concentration is above the minimum effective concentration
Define therapeutic index
The maximum tolerated concentration divided by the minimum effective concentration - gives an idea of potential to overdose
Define half life
The time in which the amount of drug in the body decreases by half
Define t-max
The time it takes to reach c-max
