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Flashcards in Sahay Deck (25)
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1

Define absorption

When a drug is released from its formulation/administration site and enters the bloodstream

2

Define distribution

The movement of a drug in the bloodstream

3

Define metabolism

A process through which the drug is biochemically modified usually through specialized enzymatic systems

4

Define excretion

Getting rid of the drug byproduct

5

Define pharmacokinetics

Movement of the drug in the body or the study of the time course of absorption, distribution, metabolism, and excretion of drugs from biological systems

6

Define pharmacodynamics

Power of the drug in the body

7

What are the four parts of pharmacokinetics?

Absorption, distribution, metabolism, excretion

8

What are two parts of pharmacodynamics?

Drug-receptor interactions and potency/efficacy

9

What is elimination?

Metabolism and excretion

10

What is one of the major considerations that account for absorption of a drug?

Route of administration

11

Where is the major site for drug metabolism?

The liver

12

Where is the major site for drug excretion?

The kidney

13

How does metabolism usually affect a drug?

Makes it more hydrophilic

14

Define bioavailability

The rate and extent to which an active drug ingredient or therapeutic moiety is absorbed from a drug product and becomes available at the site of action

15

Define bioequivalence

The comparison of bioavailabilities of different formulations, drug products, or batches of the same drug product

16

Define MEC

Minimum effective concentration - below there is no effect

17

Define MTC

Maximum tolerated concentration - above is toxic

18

Define AUC

Area under curve - shows drug absorption/elimination over time

19

Define onset time

The amount of time until the drug starts to work

20

Define intensity

The maximum concentration reached

21

Define duration of action

The amount of time the concentration is above the minimum effective concentration

22

Define therapeutic index

The maximum tolerated concentration divided by the minimum effective concentration - gives an idea of potential to overdose

23

Define half life

The time in which the amount of drug in the body decreases by half

24

Define t-max

The time it takes to reach c-max

25

What are two important things when considering oral drug absorption?

Drugs must be unionized to cross barriers and pH changes dramatically throughout the body