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Pathology II > Salivary Gland Pathology > Flashcards

Salivary Gland Pathology Flashcards

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1
Q

Label the following structures of the salivary gland unit:

A

A- Stratified squamous epithelium
B- Extralobular duct
C- Striated duct
D- Intercalated duct
E- Acinar cells
F- Myoepithelial cells

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2
Q

Label the following structures of the salivary gland unit:

A

A- Acinus
B- Intercalated duct
C- Striated duct
D- Excretory duct

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3
Q

List the MAJOR salivary glands: (3)

A
  1. Parotid
  2. Submandibular
  3. Sublingual
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4
Q

List the locations of the MINOR salivary glands: (7)

A
  1. Palate
  2. Buccal mucosa
  3. Tongue
  4. Floor of mouth
  5. Labial mucosa
  6. Retromolar pad
  7. Oropharynx
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5
Q

What can be seen in the following histological slide?

A

Parotid gland

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6
Q

What can be seen in the following histological slide?

A

Parotid gland- pure serous

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7
Q

The parotid gland is a _____ gland

A

pure serous

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8
Q

What can be seen in the following histological slide? What are the dark staining purple areas?

A

Serous acini- zymogen granules

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9
Q

What can be seen in the following histological slide?

A

Submandibular gland

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10
Q

The submandibular gland is a _____ gland

A

seromucous

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11
Q

What can be seen in the following histological slide?

A

Sublingual gland

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12
Q

The sublingual gland is a _____ gland

A

mucoserous

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13
Q

What can be seen in the following histological slide?

A

sublingual gland

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14
Q

List the distribution of the following minor salivary glands:

a) Palate
b) Tongue
c) Lips
d) Cheeks
e) Retromolar

A

a) Palate: 60%
b) Tongue: 10%
c) Lips: 10%
d) Cheeks: 10%
e) Retromolar: 10%

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15
Q

Minors salivary glands of the tongue include: (3)

A
  1. Glands of Von Ebner
  2. Glands of Blandin & Nuhn
  3. Glands of Weber
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16
Q
  • Glands of Von Ebenr
  • Glands of Blandin & Nuhn
  • Glands of Weber

These are all:

A

Minor salivary glands of the tongue

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17
Q

List the location & type of minor salivary of the tongue:

Glands of Von Ebner

A

Location: circumvallate papillae
Type: Serous

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18
Q

List the location & type of minor salivary of the tongue:

Glands of Blandin & Nuhn

A

Location: Anterior ventral
Type: Mucous

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19
Q

List the location & type of minor salivary of the tongue:

Glands of Weber

A

Location: Posterior lateral border
Type: Mucous

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20
Q

What minor salivary gland is seen below?
Location?
Type?

A

Glands of Von Ebner
Circumvalate papillae
Serous

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21
Q

What minor salivary gland is seen below?
Location?
Type?

A

Glands of Weber
Foliate papillae
Mucous

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22
Q

What minor salivary gland is seen below?
Location?
Type?

A

Glands of Blandin & Nuhn
Anterior ventral
Mucous

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23
Q

A mucous extravasation reaction =

A

mucocele

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24
Q

Diagnose the following image:

A

mucocele

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25
Diagnose the following image:
mucocele
26
The following histological and clinical images show:
mucous extravasation reaction (mucocele)
27
The following histological image shows:
mucocele
28
The following histological and clinical images show:
mucocele
29
Diagnose the following image:
mucocele
30
Diagnose the following image:
Ranula
31
When mucin dissects through mylohyoid muscle presenting as a neck mass:
Ranula
32
Diagnose the following image:
Ranula
33
What is represented by this schematic?
Sialolith
34
Diagnose the following image:
Sialolith
35
What structures are involved in a sialolith?
Submandibular gland (deep lobe) & Wharton's duct
36
Diagnose the following images:
Sialolith
37
Diagnose the following radiographic image:
Sialolith
38
Diagnose the following image:
Sialolith
39
What can be seen in the following histological image?
Sialolith
40
Diagnose the following image:
Necrotizing sialometaplasia
41
Diagnose the following image:
Necrotizing sialometaplasia
42
Diagnose the following image:
Necrotizing sialometaplasia
43
- autoimmune disorder -dry mouth & dry eyes - primary vs. secondary - bilateral enlargement of parotid gland
Sjogrens syndrome
44
What are some syndromes one may experience with Sjogrens syndrome:
1. dry mouth & eyes 2. B/L enlargement of parotid gland
45
What are some characteristic lab values of Sjogren syndrome?
1. anti-SS-A 2. anti-ss-B 3. RF 4. ANA
46
If a patient presents with benign lymphoepithelial lesion (BLEL) you may suspect:
Sjogrens syndrome
47
An autoimmune disease considered a form of Sjogrens syndrome in which the salivary and lacrimal glands become enlarged:
Mikulicz's disease
48
-BLEL -Mikulicz's These are both associated with:
Sjogren's syndrome
49
Diagnose the following image:
Sjogren's syndrome
50
Diagnose the following image:
Sjogren's syndrome
51
The smalDiagnose the following images:
Sjögren's syndrome
52
Describe the tumor distribution of the major salivary glands: A) Parotid gland B) Submandibular C) Sublingual
A) Parotid gland benign 50% malignant 50% B) Submandibular benign 40% malignant 60% C) Sublingual benign 20% malignant 80%
53
Describe the tumor distribution of the minor salivary glands in the following areas: A) Palate B) Buccal mucosa C) Upper labial mucosa D) Lower labial mucosa E) Tongue F) Floor of mouth G) Retromolar pad
A) Palate b: 50% m: 50% B) Buccal mucosa b: 50% m: 50% C) Upper labial mucosa b: 80% m: 20% D) Lower labial mucosa b: 15% m: 85% E) Tongue - up to 90% malignant F) Floor of mouth - up to 90% malignant G) Retromolar pad - up to 90% malignant
54
Describe the following for a BENIGN salivary gland neoplasm: growth rate: induration: symptomatology: ulceration:
growth rate: SLOW GROWTH induration: MOVABLE symptomatology: ASYMPTOMATIC ulceration: INTACT MUCOSA
55
Describe the following for a MALIGNANT salivary gland neoplasm: growth rate: induration: symptomatology: ulceration:
growth rate: RAPID GROWTH induration: FIXED symptomatology: SYMPTOMATIC ulceration: ULCERATED
56
Give some examples of benign salivary gland tumors: (5)
1. benign mixed tumor (pleomorphic adenoma) 2. monomorphic adenoma 3. Warthin's tumor (papillary cystadenoma lymphomatosum) 4. oncocytoma 5. ductal papillomas
57
A papillary cystadenoma lymphomatosum may also be called:
Warthin's tumor
58
A benign mixed tumor of the salivary gland may also be called:
Pleomorphic adenoma
59
Most common salivary gland neoplasm:
pleomorphic adenoma
60
Pleomorphic adenomas are most common in:
middle-aged females
61
Describe a pleomorphic adenoma:
painless, slow growing mass
62
Diagnose the following image:
Pleomorphic adenoma
63
Diagnose the following image:
Pleomorphic adenoma
64
Diagnose the following image:
Pleomorphic adenoma
65
Describe the histology of pleomorphic adenoma (3):
1. variable histology 2. mixture of ductal & myoepithelial elements 3. encapsulated
66
- most common salivary gland neoplasm - middle-aged females - painless slow-growing mass - encapsulated
Pleomorphic adenoma
67
- upper lip - middle-aged females - painless slow-growing mass - thin fibrous capsule - uniform pattern
Monomorphic adenoma
68
Diagnose the following image:
Monomorphic adenoma
69
Describe the histology of a monomorphic adenoma: (5)
1. uniform pattern 2. single layered cords of columnar or cuboidal epithelium 3. may demonstrate papillary projections 4. loose connective tissue stroma, with prominent vascularity 5. thin fibrous capsule
70
The following histological characteristics describe: 1. uniform pattern 2. single layered cords of columnar or cuboidal epithelium 3. may demonstrate papillary projections 4. loose connective tissue stroma, with prominent vascularity 5. thin fibrous capsule
monomorphic adenoma
71
The following histological characteristics describe: 1. variable histology 2. mixture of ductal & myoepithelial elements 3. encapsulated
pleomorphic adenoma
72
Papillary cystadenoma lymphomatosum =
Warthin's tumor
73
- 2nd most common benign salivary gland neoplasm - parotid gland - bilateral - middle-aged males (seen fewer in blacks) - smoking - painless slowly growing nodular mass
Papillary cystadenoma lymphomatosum (Warthin's tumor)
74
What is the second most common benign salivary gland neoplasm?
Papillary cystadenoma lymphomatosum (Warthin's tumor)
75
Where does a Papillary cystadenoma lymphomatosum (Warthin's tumor) occur?
parotid gland (B/L)
76
Papillary cystadenoma lymphomatosum (Warthin's tumor) is most often seen in:
middle-aged males (fewer blacks)
77
_____ is a risk factor for Papillary cystadenoma lymphomatosum (Warthin's tumor)
smoking
78
Describe Papillary cystadenoma lymphomatosum (Warthin's tumor):
painless slow-growing nodular mass
79
Diagnose this image:
Papillary cystadenoma lymphomatosum (Warthin's tumor)
80
Describe the histology of Papillary cystadenoma lymphomatosum (Warthin's tumor): (3)
1. oncocytic ductal epithelium (uniform double rows) 2. lymphoid aggregate 3. papillary cystic configuration
81
The following histological characteristics describe: 1. oncocytic ductal epithelium (uniform double rows) 2. lymphoid aggregate 3. papillary cystic configuration
Papillary cystadenoma lymphomatosum (Warthin's tumor)
82
What is seen in the following histological image?
Papillary cystadenoma lymphomatosum (Warthin's tumor) (KEY: DOUBLE ROWS)
83
What is seen in the following histological image?
Papillary cystadenoma lymphomatosum (Warthin's tumor) (KEY: DOUBLE ROWS)
84
- rare salivary gland neoplasm - large epithelial cells, oncocytes - females, 8th decade - parotid gland - painless slow-growing mass - multifocal
Oncocytoma
85
A rare salivary gland neoplasm that is multifocal and comprised of large epithelial cells:
oncocytoma
86
Describe the cells found in an oncocytoma:
large epithelial cells (oncocytes)
87
______ especially at age _____ are most at risk for oncocytomas
females; 80s
88
Describe an oncocytoma:
painless, slow-growing multifocal mass
89
Diagnose this image:
oncocytoma
90
Describe the histology of an oncocytoma: (3)
1. large polyhedral cells abundant in granular eosinophilic cytoplasm- mitochondria 2. limited stroma- thin fibrovascular septa 3. lymphoid infiltrate
91
1. large polyhedral cells abundant in granular eosinophilic cytoplasm- mitochondria 2. limited stroma- thin fibrovascular septa 3. lymphoid infiltrate The following histological characteristics describes:
oncocytoma
92
Describe the histology of necrotizing sialometaplasia: (3)
1. pseudoepitheliomatous hyperplasia 2. sialometaplasia 3. coagulative necrosis of the glands
93
1. pseudoepitheliomatous hyperplasia 2. sialometaplasia 3. coagulative necrosis of the glands The following histological characteristics describes:
Necrotizing sialometaplasia
94
List some examples of MALIGNANT salivary gland tumors: (6)
1. mucoepidermoid carcinoma 2. adenoid cystic carcinoma 3. polymorphous low-grade adenocarinoma 4. acinic cell carcinoma 5. carcinoma ex-mixed tumor 6. adenocarcinoma NOS
95
- The most common malignant salivary gland neoplasm - Middle-aged females - clinically mistaken for a mucocele
Mucepidermoid carcinoma
96
What is the most common malignant salivary gland neoplasm?
Mucoepidermoid carcinoma
97
Mucoepidermoid carcinoma most commonly occurs in:
middle-aged females
98
What is commonly misdiagnosed for a mucoepidermoid carcinoma?
mucocele
99
Diagnose the following image:
mucoepidermoid carcinoma
100
Diagnose the following image:
mucoepidermoid carcinoma
101
Diagnose the following image:
mucoepidermoid carcinoma
102
Diagnose the following image:
mucoepidermoid carcinoma
103
Describe the histological characteristics o a mucoepidermoid carcinoma: (3)
1. mucous producing cells 2. epidermoid (squamous) cells 3. may be cystic and/or solid
104
The following histological characteristics describe: 1. mucous producing cells 2. epidermoid (squamous) cells 3. may be cystic and/or solid
mucoepidermoid carcinoma
105
- Best recognized salivary gland tumor - Middle-aged females - Slow-growing mass - Painful
Adenoid cystic carcinoma
106
What is the "best recognized" salivary gland tumor?
Adenoid cystic carcinmoma
107
Adenoid cystic carcinmoma is most commonly seen in:
middle-aged females
108
Adenoid cystic carcinmoma can be described as ____ growing and ____
slow-growing; painful
109
Diagnose the following image:
Adenoid cystic carcinoma
110
Diagnose the following image:
Adenoid cystic carcinoma
111
Diagnose the following image:
Adenoid cystic carcinoma
112
Diagnose the following image:
Adenoid cystic carcinoma
113
Diagnose the following image:
Adenoid cystic carcinoma
114
Describe the histological characteristics of an Adenoid cystic carcinmoma: (4)
1. myoepithelial & ductal cells 2. perineural & perivascular invasion 3. cribriform pattern 4. SWISS CHEESE
115
The following histological characteristics describe: 1. myoepithelial & ductal cells 2. perineural & perivascular invasion 3. cribriform pattern 4. SWISS CHEESE
Adenoid cystic carcinoma
116
What pathology can be described as "Swiss cheese"
Adenoid cystic carcinoma
117
The following histological image is characteristic of:
adenoid cystic carcinoma (KEY: SWISS CHEESE)
118
The following histological image is characteristic of:
adenoid cystic carcinoma
119
PLGA:
Polymorphous Low-Grade Adenocarinoma
120
- common malignant MINOR salivary gland neoplasm - middle-aged females - favors palate
Polymorphous Low-Grade Adenocarinoma (PLGA)
121
Diagnose the following image:
Polymorphous Low-Grade Adenocarinoma
122
Diagnose the following image:
Polymorphous Low-Grade Adenocarinoma
123
Describe the histology of Polymorphous Low-Grade Adenocarinoma: (4)
1. deceptive uniform appearance 2. different growth patterns 3. perineural & perivascular invasion 4. indian filing
124
The following histological characteristics describe: 1. deceptive uniform appearance 2. different growth patterns 3. perineural & perivascular invasion 4. indian filing
Polymorphous Low-Grade Adenocarinoma
125
- parotid gland - serous acinar differentiation - middle-aged females - slow-growing - low-grade malignancy
Acinic cell carinoma
126
Diagnose the following image:
acinic cell carcinoma
127
Diagnose the following image:
acinic cell carcinoma
128
Describe the histology of an acinic cell carcinoma: (3)
1. well circumscribed 2. may be infiltrative 3. serous acinar cell (abundant granular basophilic cytoplasm and a round, stained eccentric nucleus)
129
The following histological characteristics describe: 1. well circumscribed 2. may be infiltrative 3. serous acinar cell (abundant granular basophilic cytoplasm and a round, stained eccentric nucleus)
acinic cell carcinoma
130
- Long-standing pleomorphic adenoma - older adults - rapid growth - pain & ulceration
Carcinoma ex-pleomorphic adenoma
131
Diagnose the following image:
Carcinoma ex-pleomorphic adenoma
132
Describe the histological characters of Carcinoma ex-pleomorphic adenoma: (5)
1. typical benign mixed tumor 2. malignant degeneration 3. cellular pleomorphism 4. abnormal mitotic activity 5. capsular invasion
133
The following histological characteristics describe: 1. typical benign mixed tumor 2. malignant degeneration 3. cellular pleomorphism 4. abnormal mitotic activity 5. capsular invasion
Carcinoma ex-pleomorphic adenoma
134
- uncommon salivary gland neoplasm - middle-aged females
adenocarcinoma NOS
135
Diagnose the following image:
adenocarcinoma NOS
136
Describe the histology of adenocarcinoma NOS:
variable
137

Pathology II (17 decks)

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