Sarcoidosis Flashcards Preview

Respiratory Medicine > Sarcoidosis > Flashcards

Flashcards in Sarcoidosis Deck (3):
1

Sarcoidosis?

  • Sarcoidosis is a multisystem disorder of unknown aetiology characterised by non-caseating granulomas.
  • It is more common in young adults and in people of African descent

2

Features?

 

  • acute: erythema nodosum, bilateral hilar lymphadenopathy, swinging fever, polyarthralgia
  • insidious: dyspnoea, non-productive cough, malaise, weight loss
  • skin: lupus pernio
  • hypercalcaemia: macrophages inside the granulomas cause an increased conversion of vitamin D to its active form (1,25-dihydroxycholecalciferol)

3

Syndromes associated with sarcoidosis?

 

Lofgren's syndrome:

  •  is an acute form of the disease characterised by bilateral hilar lymphadenopathy (BHL),
  • erythema nodosum, fever and polyarthralgia. It usually carries an excellent prognosis


In Mikulicz syndrome*:

  •  there is enlargement of the parotid and lacrimal glands due to sarcoidosis,
  • tuberculosis or lymphoma


Heerfordt's syndrome (uveoparotid fever):

  • there is parotid enlargement, fever and uveitis secondary to sarcoidosis

*this term is now considered outdated and unhelpful by many as there is a confusing overlap with Sjogren's syndrome