- Sarcoidosis is a multisystem disorder of unknown aetiology characterised by non-caseating granulomas.
- It is more common in young adults and in people of African descent
- acute: erythema nodosum, bilateral hilar lymphadenopathy, swinging fever, polyarthralgia
- insidious: dyspnoea, non-productive cough, malaise, weight loss
- skin: lupus pernio
- hypercalcaemia: macrophages inside the granulomas cause an increased conversion of vitamin D to its active form (1,25-dihydroxycholecalciferol)
Syndromes associated with sarcoidosis?
- is an acute form of the disease characterised by bilateral hilar lymphadenopathy (BHL),
- erythema nodosum, fever and polyarthralgia. It usually carries an excellent prognosis
In Mikulicz syndrome*:
- there is enlargement of the parotid and lacrimal glands due to sarcoidosis,
- tuberculosis or lymphoma
Heerfordt's syndrome (uveoparotid fever):
- there is parotid enlargement, fever and uveitis secondary to sarcoidosis
*this term is now considered outdated and unhelpful by many as there is a confusing overlap with Sjogren's syndrome