SARS-CoV-2

Question 1

SARS-CoV

Answer 1

Severe Acute Respiratory Virus

Appeared in humans 02-03

Caused just over 8000 cases, easily controllable with standard disease control (Contact tracing)

Question 2

MERS-CoV

Answer 2

Middle East Respiratory Syndrome

(2012-)

Still circulating in middle east (thought to originate from camels, which received it from another species)

Question 3

Does hydroxychloroquine work for covid

Answer 3

ffs no it does not

Question 4

Remdesivir

Answer 4

Anti-viral drug shown to improve recovery period in Covid-19 patients - does not seem to have impact on mortality

Causes termination of RNA synthesis

Question 5

Dexamethasone

Answer 5

Covid-19 treatment shown to have a positive effect on mortality

Anti-inflammatory

Cheap (old drug)

Question 6

Passive immunisation against covid-19

Answer 6

Convalescent plasma (plasma from previously infected patients)
 - not very effective

Monoclonal antibodies
- effective but is at risk of redundancy through antigenic drift

Question 7

Monoclonal antibodies used against Covid-19

Answer 7

Ronapreve, Sotrovimab

Question 8

Molnupiravir

Answer 8

Antiviral drug against Covid-19

Question 9

Tociluzamab

Answer 9

Anti-IL6 monoclonals; used to treat covid-19

Question 10

Are anti-coagulants used to treat covid-19

Answer 10

Yes (probably)

Question 11

Describe the nucleic acids of SARS-CoV-2

Answer 11

Positive-sense ssRNA

Question 12

RBD

Answer 12

Receptor binding domain; responsible for the virus binding to host cells

Question 13

Coronavirus replication cycle

Answer 13

Virus binds to cell receptor

Entry by endocytosis

Fusion of viral envelope with endocytotic membrane to uncoat the genome

Genome is copied; translated

Assembly of replicated RNA and proteins

Virus released

Question 14

ACE2

Answer 14

Angiotensin Converting Enzyme 2

Receptor that SARS-CoV-2 binds to (on human cells)

Question 15

ChadOx1

Answer 15

Oxford Vaccine for Covid-19

Uses chimpanzee adenovirus modified to avoid replication