Schizophrenia Flashcards
(34 cards)
What is schizophrenia?
- it’s a type of psychosis, a severe mental disorder in which thoughts & emotions are so impaired that contact is lost with external reality.
- most likely to be diagnosed between ages of 15-35, men and women being equally effected
How is schizophrenia diagnosed (& using what)?
- diagnosed using the DSM (diagnostic and statistical manual, must meet a criteria of positive and negative symptoms.
What does positive symptoms of schizophrenia mean and what are they?
positive symptoms- adding on to patients everyday life.
Hallucinations- bizarre and unreal perceptions of the environment. Auditory (hearing voices), Visual (seeing things), Olfactory (smelling things), Tactile (feeling things)
Delusions- Bizarre beliefs that seem real to the person. Can be persecutory (believing there being followed or spied on). Can involve beliefs about being famous (delusions of grandeur)
more about believing something is happening to themselves as individuals.
What does negative symptoms of schizophrenia mean and what are they?
negative symptoms- taking away from the patients everyday life.
Speech poverty- decreased speech fluency (reflective of slow/blocked thoughts), produce fewer words in a given time, less complex syntax
Avolition- reduction of interests and desires, unable to persist with goal-directed behaviour, self-initiated activities are available patient but will not partake due to mental distress.
What are the criteria’s that a patient must fullfil in order to be diagnosed with schizophrenia?
Criteria A; must have two symptoms from- delusions, hallucinations, disorganised speech, grossly disorganised or catatonic behaviour (neg symptoms)
Criteria B; significant amount of time since the start of one or more major areas of functioning decrease below the level achieved prior the onset.
Criteria C; continuous signs of disturbance persist for at least 6 months - must include at least 1 month of symptoms from Criteria A.
What is diagnostic reliability?
must be repeatable (clinicians must be able to reach the same conclusion about patients conditions at two different points in time, test-re-test reliability & inter-rater reliability)
Discuss interrater reliability for classification of schizophrenia. (Kappa scores)
- measured by a scale found on a Kappa score- 0.7/0.8 or above is considered good reliability
- 1 indicates a perfect agreement
Discuss cultural differences in the classification of schizophrenia.
culture DOES HAVE an influence of the diagnosis of schiz.
COPELAND (1971)
- US & British psychiatrists given description of a patient
- 69% of US diagnosed patient with schiz
- 2% of British diagnosed patient with schiz
LUHRMAN (2015)
- interviewed 60 adults who ‘heard voices’
- 20 Ghanaians, 20 Indian, 20 American.
- African & Indian reported having pos experience with their voices (playful & offering advice)
- US said voices violent & hurtful
What is meant by validity of the classification system of schhizophrenia?
refers to the extent that classification systems (DSM) measure what they claim to.
What is gender bias in diagnosis?
- occurs when accuracy of diagnosis is dependent on the gender of patient, judgements can vary. Can be based on stereotypical beliefs held about gender.
What is symptom overlap?
- considerable overlap between symptoms of schiz and another disorder, for example bipolar and schiz.
Makes DSM less valid as patients could be diagnosed incorrectly.
Ellason & Ross (1955)
people with DID have more schizophrenic symptoms (suggested by DSM) than schiz individuals do.
Evaluate the reliability & validity in diagnosis & classification of schizophrenia.
limitation; research suggests that there is gender bias in diagnosis. Loving & Powell (1988) found a case described as ‘male’ was more likely to be diagnosed with schiz than the same case labelled as ‘female’. TMB shows that diagnosis of schiz is not applied to everyone in the same way, this could lead to missed diagnoses or incorrect diagnosis. Lacks validity.
limitation; co-morbidity can have negative consequences on patients diagnosed. Webber (2009) found schiz was co-morbid with medical problems such as hypertension (high blood pressure). Also found that co-morbidity was associated with a lower standard of medical care. TMB patients will face poorer care due to being diagnosed, this could have a negative effect on physical health as well as mental. Lacks validity.
limitation; lack of interrater reliability. Whaley (2001) found kappa score to be as low as 0.11 in diagnosis of schiz. TMB shows DSM is inconsistent as score is below 0.7, in order to have high reliability score needs to be >0.7. Diagnosis of schiz is unreliable.
limitation; lack of agreement on symptoms. Mojtabi & Nicholson (1955) found that psychiatrists produced an interrater reliability score of 0.4 when deciding what was considered as ‘bizarre’ & ‘non-bizarre’ delusions. TMB psychiatrists cannot distinguish between two important factors which are crucial in diagnosis of schiz. Kappa score of 0.7 required to be considered reliable. Hard to diagnose schiz & simply based off of the opinion of a Dr. not clear, objective rules. Unreliable.
What is co-morbidity?
when two or more conditions occur together, common among patients with Schiz (substance abuse, anxiety, depression)
Buckley (2009)
estimated that co-morbid depression occurs in 50% of patients.
Biological explanations for schiz- Genetic factors (family, twin & adoption studies)
genetic factors- can be genetically passed on, higher chance of getting schiz if a blood member has it.
FAMILY STUDIES
- established that schiz is more common among biological relatives
STUDY- Gottesman
children w/ 2 schiz parents- concordance rate= 46%
children w/ 1 schiz parent- 13%
siblings who both have schiz= 9%
TWIN STUDIES
MZ twins more likely to develop schiz
STUDY (2004)
pooled data for all schiz twin studies
MZ- 40.4%
DZ- 7.4%
because concordance rate not 100%, even for MZ twins, schiz is not predisposed, other factors contribute.
ADOPTION STUDIES
TINERARI (2004)
- found that adopted children with a bio schiz mother were MORE likely to develop schiz than adopted children of mothers without schiz- Supports genetic link.
Biological explanations for schiz- The dopamine hypothesis (increasing/decreasing dopaminergic activity & revised dopamine hypothesis)
neurotransmitter dopamine- high levels of this are a cause of positive symptoms of schiz.
INCREASING DOPAMINIERGIC ACTIVITY
Amphetamine- stimulates nerve cells containing dopamine- causes a normal individual to have symptoms of a schiz episode, disappear with removal of drug
*hyperdopaminergic- high levels of dopamine in subcortex = pos symptoms
DECREASING DOPAMINIERGIC ACTIVITY
Dopamine antagonists- reduce activity in neural pathways of the brain- eliminate symptoms of such as hallucinations & delusions
*hypodopaminergic- lower levels of dopamine in cortex, linked with neg symptoms.
REVISED DOPAMINE HYPOTHESIS
- pos symptoms caused by excess of dopamine in subcortical areas
- neg & cog symptoms caused by deficit of dopamine.
Biological explanations for schiz- Neural correlates (prefrontal cortex, hippocampus, grey matter & white matter)
- schiz is down to abnormalities in the brain; structure & functioning of brain is correlated with pos + neg symptoms.
PREFRONTAL CORTEX
- PFC; executive control (planning, reasoning & judgement)
- PFC impaired for schiz patients
- cog symptoms result of deficit in PFC & it’s connections with areas (hippocampus)
HIPPOCAMPUS
- anatomical changes in schiz patients
- deficits in nerve connections between hippocampus & PFC
- working memory impairments (cog symptoms)
- dysfunction in hippocampus can influence production of dopamine release in basal ganglia- affecting processing of info in PFC
GREY MATTER
- less of it in schiz patients
- enlarged ventricles = neg symptoms
CANNON (2014)
- found ppl at high risk of schiz have less grey matter & enlarged ventricles
WHITE MATTER
- in brain & spinal cord- made of nerve fibres & myelin
- reduced myelination in schiz patients compared to normal
Evaluation of biological explanations for schizophrenia.
strength; evidence from treatment for dopamine hypothesis. Leucht’s meta-analysis found that all antipsychotics are more effective than the placebo in reducing schiz symptoms. TMB highlights importance of drug therapy to alleviate symptoms and symptoms are actually a result of a neurochemistry issue. Supporting dopamine hypothesis as an explanation of schiz.
strength; research support for significance of grey matter deficits. Vita (2012), schiz patients had less grey matter in parietal, temporal & frontal lobes. TMB evidences the link between less grey matter and schiz symptoms, this could be recognised during brain scans and early intervention can be made. Thus supporting neural correlates as an explanation of schiz.
limitation; influence of environmental factors in family studies. Findings from family studies are limited by the fact that family’s typically share the same env as well as genes (cannot be separated). TMB suggests that differences in concordance rates between MZ & DZ twins reflect nothing more than env differences. Limiting use of family studies to study biological explanations for schiz.
limitation; twin studies- higher concordance rates in MZ twins may be due to env rather than genes. Studies assume that DZ 7 MZ twins studies are equivocal however MZ twins are often treated as ‘the twins’ not two separate individual where as DZ twins are. TMB suggests that differences in findings reflect nothing more than env differences. Limiting role of twin studies to look at bio explanations for schiz.
Psychological explanations for schiz- Family dysfunction (double bind), expressed emotion.
FAMILY DYSFUNCTION
claims that schiz is caused by abnormal patterns of communication in families.
BATESON (1956)- DOUBLE BIND
- children who receive contradictory messages from their parents are more likely to develop schiz. (mum tells son ‘love you’ but turns head in disgusting)
- child receive contradictory messages on two different communication levels.
- child’s response is incapacitated- one message invalidates the other
- prevents the development of internally coherent construction of reality- manifests itself as schiz symptoms
EXPRESSED EMOTION
- known as a communication style
- env with high degree of EE (hostility & criticism), causes stress
- EE primarily associated with relapse of schiz - patients returning to a env with high EE are x4 more likely to relapse than those without.
- suggests people with schiz have less tolerance for an intense stimuli (env)
Psychological explanations for schiz- cognitive explanations (for delusions, for hallucinations)
COGNITIVE EXPLANATIONS
- dysfunctional thought processing- inability to reflect on ones own thoughts/emotions = pos symptoms
COG DELUSIONS- delusions are patients interpretations of their experiences
- voices interpreted as people criticising them, flashes of light usually a signal from God. Patients not willing to consider they may be wrong.
Central control- inner voice- cannot supress, can be triggered by other thoughts
COG HALLUCINATIONS
ALEMAN (2001)
- hallucination prone patients have difficulty distinguishing imagery & sensory based perception.
- inner representation of an idea can override actual sensory stimulus- manifests itself as real to the individual.
- not corrected by disconfirming evidence because of poor cognitive processing
Evaluation of psychological explanations of schizophrenia.
strength; family dysfunction has research support. Tienari (1994) found adopted kids with bio schiz parents more likely to get it but only if adopted family was rated as disturbed. TMB suggests that schiz only manifests itself under appropriate env conditions & genetic info alone is not sufficient enough for schiz. Validity.
strength; real- world applications- development of family therapy. Gibrey (2006) suggested that if family interactions can be problematic then they can be constructed to become useful and health producing. TMB helps schiz patients with family issues resolve issues, meaning less likely to relapse. Validity.
limitation; individual differences in schiz patients vulnerability to EE. Aluffer (1998) found 25% of schiz patients showed no psychological response to stressful comments from relatives. TMB suggests that not all sufferers are affected by same triggers, challenges the comments that relapse is caused by EE therefore may be alternative explanations for relapse. Limiting use of EE in psychological explanations of schiz.
limitation; little evidence for double-bind theory. Berger (1965), schiz patients reported a high number of double-bind statements from their mothers than non-schiz parents. TMB schiz patients are often a lot more sensitive, this means they may have perceived their mothers comments in a neg way. comparing statements from schiz & non-schiz patients is not valid, more measuring of how it’s perceived. Limits research for schiz.
Drug therapy for schizophrenia. (antipsychotics)
ANTIPSYHCOTICS
- treat psychotic illnesses
- helps individual return to normal functioning by decreasing symptoms
- reduces dopaminergic transmission
TYPICAL ANTIPSYCHOTICS
CHLORPROMAZINE
- treats pos symptoms only (hallucinations & thought disturbances)
- dopamine antagonists; bind to D2 receptors in mesolimbic pathway (less dopamine, less hallucinations)
- has side effects
KAPUR (2000)
- 60%-75% of receptors need to be blocked in order for it to be effective.
ATYPICAL ANTIPSYCHOTICS
RISPIDRONE/ CLOZAPINE
- treats neg and pos symptoms
- carry lower risk of extrapyramidal side effects
- block D2 receptors but disassociate quickly after to allow normal dopamine transmission
- lower affinity for dopamine and higher for serotonin
What are the side effects of drug therapy?
Tardive dyskinesia- excessive involuntary movements of the mouth, tongue and jaw.
Agranulocytosis (atypical ONLY)- mouth, tongue and jaw movement with rashes and itchiness.
Evaluation of drug therapy.
strength; supporting evidence, Leutch’s meta-analysis, 64% of ptps relapsed after 12 months compared to 27% who relapsed after staying on meds. TMB shows drugs are affective in controlling schiz as they decrease dopamine levels . giving the placebo is shown to cause relapse which evidences that schiz is actually a result of a neurochemical imbalance not just psychological. Beneficial to suffers life- return to normal functioning supporting use of drug therapy to control schiz.
strength; cost-effective. Cheap to administer, and has a pos effect for schiz patients allowing them to live normal lives outside of institutions. TMB allows majority of individuals suffering to seek help regardless of financial status, shows drug therapy affective in alleviating symptoms also decreasing chance of relapse and rehospitalization.
limitation; has negative side effects. prolonged use of antipsychotics can cause involuntary movement of the mouth, tongue and jaw, 20-25% of patients will suffer from distorted movements. TMB shows that although they are useful in removing symptoms, not always appropriate and can provide no help to those suffering from schiz as the side effects increase the chance of stopping using the medication increasing chance of relapse. Limiting use of drug therapy as a way of controlling schiz.
limitation; biologically reductionist. Ross & Reed (2004) stated that receiving medication re-enforces the idea that there is something with the patients, prevents them from thinking about other possible stressors. TMB it can have a negative psychological impact which drug therapy doesn’t account for as it only deals with chemical imbalances but doesn’t deal with other factors like environmental ones. Limiting use of drug therapy to control schiz.
Psychological treatments for schizophrenia. - CBTp
REBT- CBT MODEL
A- activating event- triggers schiz
B- beliefs which are irrational
C- consequences (schiz symptoms)
D- dispute- challenge irrational thought
CBTp
- NICE recommended all people with schiz should be offered CBTp
- used for those who don’t take drugs or do but are still experiencing symptoms
- patients encouraged to trace back to origin of symptoms, evaluate hallucinations & delusions
- therapist may use collaborative analysis; logical, empirical, disputing techniques.
- may be set home assignments
- recommended 16 sessions
HOW IT WORKS
1. assessment
2. engagement
3. ABC model
4. Normalisation
5. critical collaborative analysis
6. developing alternative explanations