Schizophrenia Flashcards
(68 cards)
What symptoms are used to diagnose schizophrenia?
DELUSIONS
HALLUCINATIONS
DISOGANISED SPEECH
Must have one of those three symptoms.
CATONIC BEHAVIOUR
NEGATIVE SYMPTOMS e.g. affective flattening or avolition
Must have two or more of these symptoms present
What are delusions (false beliefs)?
Bizarre beliefs that seem real to the person with schizophrenia but they are not real
What is speech poverty?
Lessening of speech fluency and productivity, reflecting slow or blocked thoughts
What are hallucinations (false perceptions)?
Bizarre unreal perceptions of the environment that are usually auditory (hearing voices) but may also be visual
What is avolition?
The reduction of, or inability to initiate and persist in goal directed behaviour. Lack of motivation
What are the positive symptoms of schizophrenia?
Hallucinations, delusions
What are the negative symptoms of schizophrenia?
Speech poverty, avolition
What is reliability in terms of a schizophrenia diagnosis?
The CONSISTENCY of a measuring tool (The DSM) or other tests used in diagnosis
What is test-retest reliability in terms of a schizophrenia diagnosis?
Doctors must be able to reach the same conclusions about a patient at two different points in time.
What is inter-rater reliability in terms of a schizophrenia diagnosis?
Extent to which different assessors agree on their diagnosis. Doctors need to reach the same conclusions
What is some research that limits inter-rater reliability?
Cheniaux - Had 2 psychiatrist independently diagnose 100 patients using the DSM and ICD criteria. Doctor 1 diagnosed 26 patients with schizophrenia according to DSM and 44 according to ICD. Doctor 2 diagnosed 13 according to DSM and 24 according to ICD. Demonstrates inter-rater reliability of classification systems are subjective to interpretations of doctors
What is the evaluation for reliability?
Cultural differences in diagnosis - e.g hearing voices is good in some cultures but not others
Rosenhan - 8 pseudopatients to hospitals, claimed hearing voices saying ‘empty’, ‘hollow’, ‘thud’. After admission act normal. Lacks reliability as different hospitals gave inconsistent diagnosis
Lacks temporal validity as used out of date criteria for illness
What is validity in terms of a schizophrenia diagnosis?
The extent to which the classification of schizophrenia is an ACCURATE reflection of the illness the patient is suffering from.
What is symptom overlap?
2 or more disorders share some of the symptoms need for a classification. Decreases validity and and results in misclassification
What is co-morbidity?
Presence of two different disorders at the same time. Difficult to separate out the symptoms. Lacks validity and results in misclassification
What is the evaluation of validity?
Gender bias - may prevent schizophrenia being valid because diagnostic criteria often based off males and leads to misdiagnosis of females - Loring Powell - 56% psychiatrists gave male diagnosis only 20% gave females with same criteria
Rosenhan - 8 pseudopatients to hospitals, claimed hearing voices saying ‘empty’, ‘hollow’, ‘thud’. After admission act normal.
Lacks validity because psychiatrists misdiagnosed healthy individuals as having schizophrenia
Lacks temporal validity as used out of date criteria for illness
What genes are involved in the development of schizophrenia?
PCMI, PPP3CC AND NRG-1
How do family studies show that schizophrenia is more common in biological relatives?
Gottesman - 2 biological schizophrenic parents meant children had a concordance rate of 46%. 1 schizophrenic parent = 13% and siblings = 9%. Compared to 1% in general population.
SMALL SAMPLE
How do adoption studies show that schizophrenia is more common in biological relatives?
Separate genetics and environment.
Tienari - Of 164 adoptees with biological schizophrenic mothers, 6.7% diagnosed with schizophrenia. Of 197 control adoptees only 2% diagnosed. HOWEVER small sample
What is the evaluation of genetics as a biological explanation for schizophrenia?
Biological determinism - no free will, pre-determined risk of schizophrenia leading to negative attitudes
Nature vs nurture - Suggest nature HOWEVER monozygotic twins should have 100% concordance but don’t meaning should take interactionist approach
Methodological weakness - unrepresentative samples issues with reliability and generalisability
What is the role of dopamine in biologically explaining schizophrenia?
Dopamine neurotransmitter believed to be involved in development of schizophrenia. Important in many brain systems with a link to schizophrenia e.g. movement pathways, brain reward system
What is hyperdopaminergia?
High dopamine levels in sub-cortex. Excess dopamine receptors in Broca’s area (speech production) which may be associated with speech poverty and auditory hallucinations. Mesolimbic pathway
What is hypodopaminergia?
Reduction of activity in brain cortex. Low levels of dopamine in prefrontal cortex (responsible for thinking and decision making) may result in schizophrenic symptoms
What is the evaluation for the dopamine hypothesis?
Practical application - base for anti-psychotic drugs. Leucht study
Research support - seeman and kapur. Schizophrenia = more dopamine receptors
Biological reductionism - strength as allowed development of treatments