Schizophrenia

Question 0

Is schizophrenia more common in men or women?

Answer 0

Men

Question 1

What is the lifetime risk of developing schizophrenia?

Answer 1

0.5-1%

Question 2

What is the average age of onset

Answer 2

Around 20-30 tends to be younger in men

Question 3

What the definition of schizophrenia?

Answer 3

Mental disorder characterised by distortion of thinking and perception associated with blunted affect

Question 4

What is paranoid schizophrenia?

Answer 4

Often with persecutarory delusions

Question 5

What is hebaphrenic schizophrenia?

Answer 5

Has more negative symptoms with changeable delusions and fleeting hallucinations

Question 6

What does avolition mean?

Answer 6

Lack of motivation/ interest in life

Question 7

What are schniders first rank principles?

Answer 7

Delusional perception
3rd person auditory hallucinations
Thought echo insertion withdrawal
Passivity (somatic and made)

Question 8

Why percentage of people with schniders first rank symptoms?

Answer 8

20%

Question 9

Too much dopamine is what part of te brain gives positive symptoms?

Answer 9

Mesolimbic system

Question 10

Antipsychotics affect dopaminergic transmission in 3 main areas, what are they and what affects to antipsychotics cause?

Answer 10

Mesolimbic / mesocortical- antipsychotic
Substantia nigra - epse
Tubero-infundibular - prolactin secretion

Question 11

What are the triad of symptoms in psychosis

Answer 11

Thought disorder
Delusion
Hallucination

Question 12

What are schniders first rank principles?

Answer 12

3rd person auditory hallucinations
Thought echo, insertion, withdrawal, broadcast
Passivity (somatic and made)
Delusional perception

Question 13

What is the concordance rate of schizophrenia in MZ twins?

Answer 13

50%

Question 14

What is the difference between schizophrenia and delusional disorder?

Answer 14

Delusional disorder only has a delusion no hallucinations of blunted affect of other signs of schizophrenia, or delusion of control

Question 15

Is interlectual capacity maintained in schizophrenia?

Answer 15

Yes

Question 16

Why do antipsychotic drugs cause galactorrhoea?

Answer 16

They block dopamine receptors

Dopamine normally inhibits prolactin secretion

Question 17

What are the symptoms of hyperprolactinaemia?

Answer 17

Amenhorrea 
Galactorrhoea
Infertility 
Loss of libido
Breast enlargement 
Reduced bone density

Question 18

Which drugs are bad for hyperprolactinaemia?

Why?

Answer 18

Typical antipsychotics
Rispiridone /amisulpride

They have a greater affinity to D2 receptors

Question 19

What are the three mains categories of EPSEs?

Answer 19

Parkinson’s like symptoms
Dystonia
Akathesia

Question 20

what can you use to treat EPSEs?

Answer 20

Anticholinergics for dystonia and Parkinson’s type symptoms

For akathesia reduce or stop medications

Question 21

Antipsychotics can cause withdrawal symptoms, what are they?

Answer 21

Nausea vomiting diarrhoea

Dizzy

Tremor

Question 22

What is the only antipsychotic to reduce prolactin?

Answer 22

Aripiprazole

Question 23

Which antipsychotic causes hyper salivation?

Answer 23

Clozapine

Question 24

Which antipsychotics are less likely to cause weight gain?

Answer 24

Aripiprazole Amisulpride Haloperidol Trifluphenazine

Question 25

Which antipsychotic has least effect on the QT interval?

Answer 25

Aripiprazole

Question 26

Which generation of antipsychotics are best at treating negative symptoms?

Answer 26

Second generation

Question 27

Which antipsychotics have the lowest risk of sexual dysfunction?

Answer 27

Aripiprazole | Quetiapine

Question 28

What are the triad of symptoms in psychosis?

Answer 28

Thought disorder Hallucination Delusions

Question 29

How long to schizophrenic symptoms need to be present for a diagnosis ?

Answer 29

1 month

Question 30

How long are antipsychotics continued for after recovery?

Answer 30

1-2 years

Question 31

What psychological therapies are indicated in schizophrenia?

Answer 31

CBT Family therapy Arts therapy

Question 32

What psychosocial interventions may be used in schizophrenia?

Answer 32

Supported employment Reduced expressed aemotions Recognise release signature

Question 33

What is the prognosis for schizophrenia?

Answer 33

20% full recovery 35% long periods of remission 35% persistent mild symptoms 10% completely unresponsive

Question 34

What premier if factors predict a poor prognosis in schizophrenia?

Answer 34

Poor work Hx Poor achievement at school Social problems

Question 35

Which has a worse prognosis in schizophrenia slow onset or quick onset?

Answer 35

Slow onset and delay in treatment

Question 36

How long does the psychosis need to behind before depression in schizoaffective disorder?

Answer 36

2 weeks