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Flashcards in Schizophrenia Deck (16):
1

What is the prevalence of Schizophrenia?

1.1%

2

What can symptoms of Schizophrenia be characterised by?

Disturbances in the areas of the brain associated with thought, perception, attention, motor behaviour and emotion

3

What may Schizophrenia be accompanied with?

Cognitive deficit, anxiety, depression, self punishment

4

What signalling is involved with Schizo?

DA, glutamate, 5HT2A receptor agonists

5

What do Schizo brains tend to have?

Larger lateral ventricles and smaller left temporal lobe

6

What are the functions of the mesocortical and mesolimbic pathways?

Compulsion, reward pathways, perseverance, stereotypical behaviour effect

7

What is excess DA system associated with?

Schizophrenia, ADD, drug dependance

8

How many DA receptors are there, what are they and which ones are effected in Schizo?

GPCR, 5, the odd numbers (inhibitory ones)

9

How do amphetamines work?

Stimulate secretion of DA and other amines by inhibiting MAO on presynaptic terminals so inhibit DA and NA metabolism, displace DA and NA from vesicles so cause reuptake transporters to work in reverse

10

What are amphetamines used to treat?

Narcolepsy and ADHD

11

What are the names of the drugs that act on DA?

Phenothiazine- Dopamine D2 antagonist

12

What side effects are associated with first generation/typical antipsychotics?

Motor disturbances, extrapyramidal effects and prolactin

13

Give 2 examples of typical antipsychotics

Chlorpromazine, haloperidol

14

What did typical antipsychotics lead to?

Tardive dyskinesia

15

What examples are there of atypical antipsychotics?

Sulpride (D2), Clozapine(D1=D2, 5HT2A, mACh, H1, alpha 1), rispiridone (5HT2A, D2>D1, alpha 1, H1)

16

What is the initial effect of antipsychotics?

Increase electrical activity in mid brain neurons, this effect then subsides and is replaced by inhibition of the neurons and increase in DA receptors in limbic regions