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MTAP 2 - HEMA 2 > Secondary Hemostasis > Flashcards

Secondary Hemostasis Flashcards

(65 cards)

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1
Q

Secondary Hemostasis phases

A

Coagulation
Fibrin clot formation
Fibrin Stabilization

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2
Q

How many coagulation factors are involved

A

At least 16 procoagulants

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3
Q

Procoagulants are transported by

A

Plasma

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4
Q

Inactive form of enzymes

A

Zymogens (Procoagulant)

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5
Q

Zymogens are

A

PK
2,7,9,10,11,12,13

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6
Q

Binds, stabilized, enhance activity of respective enzymes

A

Cofactors

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7
Q

Cofactors are

A

Tissue factor, HMWK, V, VIII, Thrombomodulin, Protein Z and S

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8
Q

Serves as regulator for coagulation process

A

Control protein

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9
Q

Substrate for the enzymatic function of thrombin

A

Fibrinogen

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10
Q

Factor I is also known as

A

Fibrinogen

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11
Q

Factor II is also known as

A

Prothrombin

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12
Q

Factor III is also known as

A

Tissue thromboplastin (mixture of TF and Phospholipid)

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13
Q

Other term for FIII

A

Tissue Factor

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14
Q

FIV is also known as

A

Calcium

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15
Q

FV is

A

Proaccelerin

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16
Q

Other term for FV

A

Labile Factor, Ac globulin

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17
Q

FVI is

A

Activated form of FV

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18
Q

FVII is

A

Proconvertin

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19
Q

Other term for FVII

A

Stable Factor
SPCA (Serum Prothrombin Conversion Activator)

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20
Q

FVIII is also known as

A

Antihemophilic factor

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21
Q

Other term for VIII

A

AHG
Antihemophilic factor A

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22
Q

FIX

A

Plasma Thromboplastin Component

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23
Q

Other term for FIX

A

Christmas Factor
Antihemophilic Factor B

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24
Q

FX

A

Stuart Factor

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25
Other Term for FX
Stuart-prower Factor
26
FXI
Plasma Thromboplastin Antecedent
27
Other term for FXI
Antihemophilic factor C
28
XII
Hageman Factor
29
Other term for XII
Glass or Contact Factor
30
XIII
Fibrin Stabilizing Factor
31
Other term for XIII
FSF
32
HMWK
Fitzgerald Factor
33
Prekallekrin
Fletcher factor
34
FVIII related antigen
vWF
35
Classification of Coagulation Factors is necessary for
Diagnosis for Coagulation Factors deficiencies Mixing studies
36
classification of coagulations are
Fibrinogen group Prothrombin group Contact group
37
Fibrinogen Group are
FII, FV, FVIII, FXIII
38
Characteristics of Fibrinogen Group
Absorbed (not seen in serum) Calcium dependent Vitamin K independent
39
Prothrombin group are
FI, FVII, FIX, FX
40
Prothrombin group characteritics
Absordable and affected by COUMADIN Calcium and Vitamin K dependent Inhibited by warfarin
41
Contact Group are
XI,XII, PK, HMWK
42
Characteristics of Contact group
Not absorbed (seen in serum) Calcium and Vitamin K INDEPENDENT Involved in Coagulation Pathway
43
Reaction begins with FXII
Intrinsic Pathway
44
Primary step in Coagulation process
activation of XII
45
Complex formed in intrinsic pathway that is necessary for activation of FX
IXa : VIIIa
46
All factors in intrinsic pathway cause bleeding EXCEPT
FVII
47
Test involved in Intrinsic pathway
PT, APTT (measures XII, XI, IX, VIII)
48
Primary IN VIVIO inititation mechanism
TF:VIIa
49
Laboratry test for extrinsic pathway
PT
50
2 phases of coagulation
Initiation Propagation
51
Occurs on tissue factor expressing cells
Initiation
52
Percentage of thrombin formed in INITIATION
3-5%
53
Coagulation phase occurs in SURFACE OF PLATELETS
Propagation
54
Percentage of Prothrombin formed in PROPAGATION
95%
55
Extrinsic tenase complex that produces Small amount of FACTOR 2,9,10 (activated)
Initiation
56
1-2% present in blood in actuvated form; to be activated by TF
FVIIa
57
Provide TISSUE FACTOR
Fibroblast, Sub-endothelial cells
58
Cofactor of VIIa
TF
59
Activates low level of of FIX and FX
TF:VIIa
60
Platelets in propagation phase are activated through
Low level of thrombin in initiation phase Adhesion to exposed collagen
61
Cofactors VIIIa and Va are activated by
Thrombin
62
Generated by Initiation phase, intrinsic tenase complex
Factor IXa
63
Prothrombinase complex are
Xa:Va
64
Activates prothrombin = burst of Thrombin (95% or more)
Prothrombinase complex ( Xa:Va )
65
Thrombin (IIa) action
Cleaves fibrinogen to form fibrin clot Activates XIII to stabilize clot Binds to thrombomodulin to activae Protein C control pathway Activates TAFI

MTAP 2 - HEMA 2 (4 decks)

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