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HEMA LEC > SECONDARY HEMOSTASIS > Flashcards

SECONDARY HEMOSTASIS Flashcards

1
Q

Fibrin clot is digested by

A

plasmin

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2
Q

Sequential process by which multiple plasma
enzymes, cofactors, and other related
substances interact in sequence to form an
insoluble fibrin clot

A

Coagulation

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3
Q

May be subdivided into zymogens and cofactors

A

procoagulants

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4
Q

To maintain a complex and delicate balance
between thrombosis and abnormal bleeding

A

regulatory proteins

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5
Q

Proteins that promote clotting

A

procoagulants

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6
Q

Physiologic inhibitors

A

Present in the plasma
o Anti-thrombin III
o Complement inhibitor
o A2 macroglobulin
o A1 anti-trypsin

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7
Q

During clotting, procoagulants are sequentially
activated, producing a

A

localized thrombus

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8
Q

Factor IV is

A

calcium

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9
Q

All are serine proteases except:

A

Factor I, III, V, VIII, HMWK, XIII
(transglutaminase)

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10
Q

o Highest concentration
o Heaviest
procoagulant

A

fibrinogen

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11
Q

I PN

A

I Fibrinogen

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12
Q

II PN

A

II Prothrombin

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13
Q

III PN

A

III Tissue Factor

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14
Q

IV PN

A

IV Calcium

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15
Q

V Pn

A

V Proaccelerin

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16
Q

VIII:C

A

VIII:C Antihemophilic
Factor (AHF)

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17
Q

IX PN

A

IX Plasma
Thromboplastin
Component (PTC)

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18
Q

X PN

A

X Stuart-Prower Factor

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19
Q

XI PN

A

XI Plasma
thromboplastin
Antecedent

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20
Q

XII Factor

A

XII Hageman Factor

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21
Q

XIII

A

XIII Fibrin Stabilizing
Factor

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22
Q

Fletcher Factor

A

Prekallikrein

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23
Q

High Molecular
Weight Kininogen

A

Fitzgerald Factor
Contact Activation Factor
Williams Factor
Flaujeac Factor

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24
Q

DIVISION: Characteristic

A

Characteristic
o Fibrinogen
o Prothrombin
o Contact

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25
Q

3 Pathways

A

Intrinsic
o Extrinsic
o Common

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26
Q

group Consumed in clotting, not present in serum

A

Fibrinogen group

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27
Q

Fbrinogen Group
• Factors:

A

brinogen Group
• Factors: I, V, VIII, XIII

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28
Q

Only group that acts as substrates for PLASMIN

A

Fibri group

29
Q

Only group present in alpha granules of platelets
(except XIII and VIII:C)

A

Fibri group

30
Q

Factor XIII is cleaved by ______ when
activated

A

thrombin

31
Q

Prothrombin Group
• Factors:

A

• Factors: IX, X, VII, II

32
Q

Carboxylation of glutamic acid to gamma
glutamic carboxyl acid

A

Prothrombin group

33
Q

Adsorbed by BaSO4 and Al(OH)3

A

Proth group

34
Q

Primary group affected by Warfarin

A

Proth group

35
Q

first affected by warfarin in prothrombin group

A

Factor VII

36
Q

Inhibits epoxide reductase needed in the
reduction of Vit K

A

prothrombin group

37
Q

Not consumed in clotting, present in serum (except II)

A

prothrombin group

38
Q

Contact Group
• Factors:

A

Factors: XI, XII, HMWK, Prekallikrein

39
Q

Activated by contact with negatively charged
surfaces:

A

collagen and endothelium

40
Q

Activates intrinsic pathway and fibrinolysis

A

Contact group

41
Q

Extrinsic tenase complex activates?

A

IX and X

42
Q

Intrinsic tenase activates?

A

X

43
Q

Prothrombinase activates?

A

Prothrombin

44
Q

T OR F: Slow the activation of procoagulants and
suppress thrombin production

A

T

45
Q

TF: Ensure coagulation is localized and systemic

A

F: not systematic

46
Q

Principal regulator of the tissue factor pathway

A

Tissue Factor Pathway Inhibitor

47
Q

Synthesized by Epithelial cells and expressed on
platelets

A

Tissue Factor Pathway Inhibitor

48
Q

Not functional until Factor X is activated

A

Tissue Factor Pathway Inhibitor

49
Q

Tissue pathway factor inhibitor Inhibits coagulation via two steps:

A

o Inactivating Xa
o TFPI:Xa complex binds to TF:VIIa

50
Q

Neutralizes all serine proteases, except Factor
VIIa

A

Antithrombin

51
Q

Inactivates thrombin

A

Heparin cofactor II

52
Q

Inhibits Xa and XIa

A

ZPI (Protein Z-dependent inhibitor)

53
Q

Inhibits APC, thrombin, Xa, Xia, and urokinase

A

Protein C inhibitor

54
Q

• Activated by thrombin-thrombomodulin

A

Protein C

55
Q

Protein S as cofactor
o 40% - ???
o 60% - ???

A

Protein S as cofactor
o 40% - free (cofactor)
o 60% - bound to C4bBP

56
Q

Activated protein C inactivates Factor and

A

Factor Va and VIIIa

57
Q

Systemic and accelerated hydrolysis of fibrin by
bound plasminogen

A

Fibrinolysis

58
Q

Contains 5 glycosylated loops (kringles)

A

Plasminogen

59
Q

Enable plasminogen, along with TPA and UPA, to
bind fibrin lysine molecules during
polymerization

A

Kringles

60
Q

Digest clots by hydrolysis of arginine-related and
lysine-related peptide bonds

A

plasmin

61
Q

plasmin Capable of digesting:

A

o Plasma fibrinogen
o Factor V
o Factor VIII
o Fibronectin
o (Factor XIII)

62
Q

Hydrolyzes fibrin-bound plasminogen and convert it
to plasmin initiation fibrinolysis

A

Tissue Plasminogen Activator (TPA)

63
Q

Produced by urinary tract epithelial cells, monocytes,
and macrophages

A

Urokinase Plasminogen Activator (UPA)

64
Q

Plasma concentration: 2-4 ng/mL
• Does not bind firmly to fibrin
• Has a minor physiologic effect

A

UPA

65
Q

Primary inhibitor of free plasmin

A

Alpha-2-antiplasmin

66
Q

Prevents plasmin’s premature and uncontrolled
digestion of fibrin

A

A2A

67
Q

Activated by thrombin-thrombomodulin complex

A

Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)

68
Q

Prevents binding of TPA and plasminogen to fibrin
and blocking plasmin formation

A

TAF

69
Q

Cleaving exposed carboxy-terminal lysine residues
from fibrin

A

TAF

HEMA LEC (2 decks)

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