Secondary hemostasis - lab

Question 1

secondary hemostasis happens at the __

Answer 1

platelet membrane

Question 2

secondary hemostasis happens at the platelet membrane, the fluid phase inhibited by __

Answer 2

coagulation control proteins

Question 3

enumerate the classification of blood factors

Answer 3

• substrate
• zymogen
• serine protease
• cofactor
• calcium

Question 4

substance where an enzyme acts

Answer 4

substrate

Question 5

an enzyme precursor and the inactive forms of a coagulation factor

Answer 5

zymogen

Question 6

serine protease is the proteolytic enzymes of __ and with the __ residue in active sites

Answer 6

trypsin family, reactive seryl amino acid

Question 7

t or f: cofactors needs to be present in addition to the enzyme so a particular reaction will be catalysed.

Answer 7

true

Question 8

binds serine protease

Answer 8

cofactor

Question 9

needed for activation of coagulation factors

Answer 9

calcium

Question 10

calcium activates the coagulation factors except the __

Answer 10

contact phase

Question 11

flips to the outer surface on activation and is the phospholipid surface on which clotting enzymes assemble and is the phospholipid surface on which clotting enzymes assemble

Answer 11

phosphatidylethanolamine

Question 12

enumerate the factor/s present in common pathway

Answer 12

X, V, prothrombin, fibrinogen

Question 13

enumerate the factor/s present in intrinsic pathway

Answer 13

VIII, IX, XI, XII, prekallikrein, HMWK

Question 14

enumerate the factor/s present in extrinsic pathway

Answer 14

VII

Question 15

enumerate the factors present in absorb plasma

Answer 15

I, V, VIII, XI, XII, XIII, prekallikrein, HMWK

Question 16

enumerate the vitamin k dependent factors

Answer 16

II, VII, IX, X, XI

Question 17

enumerate the name of these coagulation factors in which, the active form is a cofactor

Answer 17

V - proaccelerin
VIII - antihemophilic factor
High molecular weight kininogen

Question 18

active form of fibrinogen

Answer 18

fibrin

Question 19

active form of factor II

Answer 19

thrombin

Question 20

active form of factor VII

Answer 20

serine protease

Question 21

enumerate the name of these coagulation factors in which, the active form is a serine protease

Answer 21

VII - proconvertin
IX - plasma thromboplastin component
X - stuart-power factor
XI - plasma thromboplastin antecedent
XII - hageman
XIII - fibrin stabilizing factor
prekallikrein

Question 22

enumerate the 3 stages of secondary hemostasis

Answer 22

1: Generation of thromboplastin
2: conversion of prothrombin to thrombin
3: conversion of fibrinogen to fibrin clot

Question 23

stage 1 - generation of thromboplastin is also known as the

Answer 23

enzymatic phase

Question 24

stage 2 - conversion of prothrombin to thrombin is also know as the

Answer 24

polymerization

Question 25

stage 3 - conversion of fibrinogen to fibrin clot is also known as the

Answer 25

coagulation/clotting

Question 26

a factor produced endothelial cells and megakaryocytes

Answer 26

von willebrand

Question 27

vWf is stored in a-granules of platelets and in ___ of endothelial cells

Answer 27

Weilbel-Palade bodie

Question 28

formation of complexes: TENASE

Answer 28

factor IXa, XIII, Calcium and PF3

Question 29

formation of complexes: factor Xa, Va, calcium , PF3

Answer 29

prothrombinase

Question 30

formation of complexes

Answer 30

- TF, factor VIIa, phospholipids, calcium - factor IXa, factor XIII, Calcium and PF3 - factor Xa, factor Va, calcium , PF3

Question 31

pathway that stars at factor XII and culminates in fibrin polymerization

Answer 31

intrinsic pathway

Question 32

extrinsic pathway is also known as the

Answer 32

tissue factor pathway

Question 33

it is where both pathway meets and ends in formation of fibrin clot

Answer 33

common pathway

Question 34

fibrinogen group is also known as the

Answer 34

thrombin sensitive group

Question 35

fibrinogen: calcium and vit k

Answer 35

calcium dependent; vit K independent

Question 36

fibrinogen involves what factor?

Answer 36

I, V, VIII, XIII

Question 37

fibrinogen group: plasma and serum

Answer 37

present in plasma, absent in serum

Question 38

fibrinogen is increased in __

Answer 38

- pregnancy - inflammatory response - women on oral contraceptives - stress

Question 39

what factor/s decreased in in-vitro storage

Answer 39

V and VIII

Question 40

prothrombin group involves what factor/s?

Answer 40

II, V, VII, IX, X, protein C and S

Question 41

prothrombin group: calcium and vit K

Answer 41

calcium and vit K dependent

Question 42

necessary for the synthesis of prothrombin in the liver

Answer 42

vitamin K

Question 43

prothrombin group: plasma and serum

Answer 43

present in serum and plasma

Question 44

prothrombin is present in serum and plasma except?

Answer 44

except factor II

Question 45

competes with vit K

Answer 45

coumarin drugs

Question 46

this require a calcium or a cofactor to bind with phospholipid surfaces

Answer 46

prothrombin

Question 47

factor/s activated in cold temp

Answer 47

VII, XI

Question 48

examples of vit K sources

Answer 48

leafy vegetables, bacteriodes fragilis, e. coli

Question 49

contact group: calcium and vit K

Answer 49

calcium and vit K independent

Question 50

contact group involves what factor/s?

Answer 50

XII, XI, Prekallikrein, HMWK

Question 51

not adsorbed, not consumed during coagulation

Answer 51

contact group

Question 52

contact group is relatively stable and requires contact of __ for activation

Answer 52

negative-charged surface

Question 53

these factor/s function in the activation of plasminogen and fibrinolytic system

Answer 53

prekallikrein and HMWK

Question 54

clot retraction: after the fibrin clot has been stabilized by what factor?

Answer 54

factor XIIIa