Secretion II: Pancreatic Biliary Flashcards

1
Q

Secretin function

A

Activate ductal cells to produce HCO3-

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2
Q

CCK function

A

Activate acinar cells to produce enzymes

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3
Q

Islets of Langerhan produce 2 hormones

A

Insulin and glucagon

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4
Q

2 endocrine hormones

A

Glucagon and insulin

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5
Q

Exocrine cells secrete

A

Enzymes

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6
Q

2 Exocrine cells

A

Ductal and acinar

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7
Q

What stimulates enzymes to go to acinar cells

A

Vagus nerve

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8
Q

Stimulus of secretin

A

Acidity and fat

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9
Q

Secretin action in stomach

A

Pepsinogen in chief cells

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10
Q

Which cells produce pepsinogen

A

Chief cells

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11
Q

Secretin receptor

A

SCTR

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12
Q

CCK stimulus

A

Fats and proteins

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13
Q

Actions of CCK in stomach

A

Increased HCl in parietal cells

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14
Q

Which cells produce HCl

A

Parietal cells

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15
Q

Which hormone produces decreased emptying

A

CCK

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16
Q

Action of CCK in acinar cells

A

Produce more enzymes

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17
Q

CCK receptor

A

CCKR2

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18
Q

PS NS stimulus

A

Distension

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19
Q

Function of PS NS in stomach

A

Increased emptying
Increased HCl in parietal cells
Increased pepsinogen in chief cells

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20
Q

Action of PS NS in ductal cells

A

Increased HCO3 production

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21
Q

PS NS receptor

A

M3 muscarinic

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22
Q

HCO3 production dependent on

A

Carbonic anhydrase and CO2

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23
Q

NBCe1-B transports…

A

HCO3- from blood into duct cell

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24
Q

NHE1 transports..

A

H+ out of cell

Na+ into cell

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25
Q

NBCe1-B and NHE1 located in

A

Basolateral membrane

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26
Q

CFTR transports…

A

Cl - and HCO3- to lumen

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27
Q

Secretin stimulates HCO3- production in ductal cells therefore… a what pH stimulates secretin

A

A low pH

28
Q

What 2 things stimulate HCO3- production

A

Secretin

PS NS

29
Q

Pancreatic amylase
Trypsin and chymotrypsin
Lipase
Are enzymes produced by

A

Acinar cells

30
Q

Pancreatic amylase breaks down

A

Carbohydrates

31
Q

Trypsin and chymotrypsin break down

A

Proteins

32
Q

Lipase breaks down

A

Lipids

33
Q

Function of zymogen granules (2)

A

Produce and store pro-enzymes

Produce trypsin inhibitors

34
Q

Trypsin is active or inactive

A

Inactive

35
Q

What enzyme turns trypsin into trypsinogen

A

Enterokinase

36
Q

Vital thing about trypsin

A

To stay inactive in pancreas

37
Q

What happens if there is trypsinogen in the pancreas

A

It will digest the cell’s protein

38
Q

Acinar cells produce … to prevent trypsin activation

A

Trypsin inhibitors

39
Q

Pro-colipase and monitor peptide are also

A

Trypsin –> trypsinogen inhibitors

40
Q

pH is lowed in acinar cells because

A

H+ is secreted

41
Q

Ductal cells have a higher pH because

A

HCO3- is secreted

42
Q

Function of biliary secretion

A

Facilitate emulsion, solubilization and absorption of fats

43
Q

The bilis HAS NO

A

ENZYMES

44
Q

Another function of bilis helping ductal cells

A

Help in alkalization, increasing pH

45
Q

Function of biliary secretion in excretion

A

Excreting bilirrubin, cholesterol, excess drugs

46
Q

Bilis helps in synthesis of

A

Hepatocytes

47
Q

Hepatic parenchyma formed primarly of

A

Hepatocytes

48
Q

Hepatocytes main function

A

Produce bilis

49
Q

Bilis goes through

A

Biliary canaliculi into biliary ducts

50
Q

Canalicular component produced by

A

Hepatocytes

51
Q

Ductal component depends on

A

Secretion of biliary ducts

52
Q

Stimulation at ductular level

A

Secretin

53
Q

Secretin stimulates what in bilis and pancreas

A

Stimulates ductal cells in pancreas

Liver ducts

54
Q

Into what does the common bile duct flow into

A

The second part of the duodenum

55
Q

What other thing flows into the second part of the duodenum

A

The pancreatic duct

56
Q

The production of bile is

A

CONSTANT

57
Q

Function of gallbladder in relation to the bilis

A

It concentrates it.

58
Q

Colestistoquin function in gallblader

A

concentration of bile

59
Q

2 bile secretion phases

A

Cephalic-gastric phase

Intestinal phase

60
Q

Cephalic-gastric phase through

A

PS NS

Before food arrives some bile is released through relaxation of Oddi spincter

61
Q

Intestinal phase stimulus

A

CCK and secretin

62
Q

Synthesis of bile from

A

Cholesterol

63
Q

Emulsion of fat to small droplets through

A

Bile salts

64
Q

Function of bile salts

A

Emulsionate fat into small droplets to increase surface area

65
Q

What breaks down fat

A

Lipase

66
Q

Small aggregates of mixed lipids and bile acid

A

Micelles

67
Q

Micelles in bile salts function

A

Maintain lipids in solution

Transport them to enterocytes for their absorption