Section 2a (NTs and locations, etc)

Question 1

Other ANS transmitters (non-adrenergic and non-cholinergic transmission) (7)

Answer 1

ATP, CGRP, neuropeptide Y, 5HT, Substance P, VIP, and NO

Question 2

What Muscarinic receptor(s) increase IP3 and DAG thus increase intracellular Ca2+ = contraction

Answer 2

M1, M3, M5

Question 3

What are the 2 cholingergic receptors?

Answer 3

Muscarinic and Nicotinic

Question 4

What muscarinic receptor(s) activate K+ channels and inhibit adenylyl cyclase = hyperpolarization (inhibits next signal)

Answer 4

M2, M4

Question 5

How does the nicotinic receptor work?

Answer 5

sodium channel –> depolarization

Question 6

What are the 2 types of nicotinic receptors?

Answer 6

muscle and neuronal type

Question 7

What are the 2 adrenergic receptors?

Answer 7

Alpha and Beta

Question 8

What does a1 do?

Answer 8

increase IP3 and DAG which increase Ca2+ = smooth muscle contraction

Question 9

What does a2 do?

Answer 9

inhibit adenylyl cyclase and decreases Ca2+ conductance, and increases K+ conductance = hyperpolarization

Question 10

What do all the B’s do?

Answer 10

Stimulate adenylyl cyclase = increase in cAMP

Question 11

Which Dopaminergic receptor(s) increase cAMP?

Answer 11

D1, D5

Question 12

Which Dopaminergic receptor(s) decrease cAMP and increase K+ conductance (hyperpolarization)

Answer 12

D2, D3, D4

Question 13

What does NE do in the heart? and by what receptor?

Answer 13

increase heart rate, and contractility via B1 (B2)

Question 14

What does ACh do in the heart? receptor?

Answer 14

decrease heart rate, and contractility via M2

Question 15

What does NE do in the skin/splanchnic vessels? receptor?

Answer 15

vasoconstriction, a1

Question 16

What does NE do in skeletal muscle? Receptors (s)?

Answer 16

vasodilation (B2) & vasoconstriction (a1)

Question 17

What does ACh do in the endothelium? receptor?

Answer 17

vasodilation, M3 (sympathetic cholinergic)

Question 18

What does NE do to Bronchiolar smooth muscle? Receptor?

Answer 18

Relaxation (Bronchodilation), B2

Question 19

NE to Bronchial glands, receptor?

Answer 19

decrease secretion, a1

Question 20

ACh to bronchiolar smooth muscle, receptor?

Answer 20

Contraction (Bronchoconstriction), M3

Question 21

ACh to bronchial glands, receptor?

Answer 21

increase secretion, M (any)

Question 22

NE to smooth muscle (logitudinal) in GI tract, receptor?

Answer 22

relaxation, a1, B2

Question 23

NE to sphincters in GI tract, receptor

Answer 23

contraction, a1

Question 24

NE to GI secretion, receptor?

Answer 24

inhibits secretion, a2

Question 25

ACh to smooth muscle (logitudinal) in GI tract, receptor?

Answer 25

contraction, M3

Question 26

ACh to sphincters, receptor?

Answer 26

relaxation, M3

Question 27

ACh to GI secretion, receptor?

Answer 27

increased secretion, M3

Question 28

NE on Urinary bladder effect(s)? receptor(s)?

Answer 28

Detrusor wall - relaxation (B2) | Sphincter - contraction (a1) - urinary continence

Question 29

ACh on Urinary bladder effect(s)? receptor(s)?

Answer 29

Detrusor wall - contraction (M3) | Sphincter - relaxation (M3)

Question 30

NE on Uterus (Pregnancy), receptor(s)?

Answer 30

a1 - contraction | B2 - relaxation

Question 31

NE on prostate, receptor?

Answer 31

a1 - contraction

Question 32

ACh on Uterus (Pregnancy), receptor?

Answer 32

M3 - contraction

Question 33

NE on radial muscle in Iris, receptor?

Answer 33

a1 - contraction (mydriasis) = pupil dilated

Question 34

ACh on circular muscle in Iris, receptor?

Answer 34

M3 - contraction (miosis) = pupil contracted

Question 35

NE on ciliary epithelium (affect secretion), receptor?

Answer 35

B - secretion of aqueous humor

Question 36

NE on ciliary muscle, receptor?

Answer 36

relaxation (far vision) - B

Question 37

ACh on ciliary muscle, receptor?

Answer 37

contraction (near vision) - M3

Question 38

NE on pilomotor smooth muscle, receptor?

Answer 38

contraction - a1

Question 39

NE on sweat glands, receptor?

Answer 39

apocrine - a1 - localized secretion (stress)

Question 40

ACh on sweat glands, receptor?

Answer 40

thermoregulatory - M - generalized secretion (Sympathetic cholinergic)

Question 41

NE on liver, receptors?

Answer 41

a1, B2 = glycogenolysis and gluconeogenesis

Question 42

NE on kidney, receptor?

Answer 42

B1 = renin release

Question 43

NE on pancreas, receptors?

Answer 43

``` a1 = decrease insulin secretion B2 = increase insulin secretion ```

Question 44

NE on adipose tissue, receptors?

Answer 44

B1, B3 = lipolysis | a2 = decrease lipolysis